Results 121 to 130 of about 7,369,478 (301)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

The Impact of a Hybrid Training Program on Point-of-Care Ultrasound (POCUS) Knowledge Acquisition & Skills among Non-ultrasound Trained Physicians

Saudi Journal of Emergency Medicine
Background: Physicians from around the world with a variety of training backgrounds practice medicine in the United Arab Emirates. Most of these physicians have not received formal ultrasound training, a critical skill to practice medicine in several ...
Maryam Alnuaimi, Hamid Shokoohi, Deborah Navedo, Roger Dias   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Differences in acoustic parameters of hammering sounds between successful and unsuccessful initial cementless cup press-fit fixation in total hip arthroplasty

Bone & Joint Open
Aims: It is important to analyze objectively the hammering sound in cup press-fit technique in total hip arthroplasty (THA) in order to better understand the change of the sound during impaction.
Yasuhiro Homma, Xu Zhuang, Taiji Watari, Koju Hayashi, Tomonori Baba, Atul Kamath, Muneaki Ishijima   +6 more
doaj   +1 more source

Growth hormone secretion during space flight and evaluation of the physiological responses of animals held in the research animal holding facility [PDF]

The spaceflight of the Research Animal Holding Facility (RAHF) on the Space Laboratory 3 (SL 3) provided the opportunity to evaluate the suitability of the RAHF for housing and maintaining experimental animals during spaceflight, and to determine changes
Fast, Thomas N., Grindeland, Richard, Mehler, William, Oyama, Jiro   +3 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

TVB C++: A Fast and Flexible Back‐End for The Virtual Brain

Advanced Science
This study introduces TVB C++, a streamlined and fast C++ Back‐End for The Virtual Brain (TVB), a renowned platform and a benchmark tool for full‐brain simulation.
Ignacio Martín, Gorka Zamora‐López, Jan Fousek, Michael Schirner, Petra Ritter, Viktor Jirsa, Gustavo Deco, Gustavo Patow   +7 more
doaj   +2 more sources

Willingness to repeat discharge on day of surgery after hip and knee arthroplasty

Bone & Joint Open
Aims: The limited documentation on patients’ perspectives on undergoing discharge on the day of surgery impedes its adoption as a standard of care. Hence, the aim of this study was to investigate whether patients were willing to repeat being discharged ...
Oddrún Danielsen, Kirill Gromov, Claus Varnum, Thomas H. Jakobsen, Mikkel R. Andersen, Manuel J. Bieder, Christoffer C. Jørgensen, Henrik Kehlet, Martin Lindberg-Larsen   +8 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Retrospective Analysis of FAST Examinations in an Emergency Department in Izmir

Van Tıp Dergisi
INTRODUCTION: Focused Assessment with Sonography for Trauma (FAST) is a widely used ultrasonographic protocol in emergency departments for rapidly detecting intra-abdominal free fluid in trauma patients. While effective, its limited sensitivity for small
Efe Kanter, Semih Musa Coşkun, Burak Acar, Mehmet Göktuğ Efgan, Adnan Yamanoğlu, Mustafa Agah Tekindal, Fatih Esat Topal   +6 more
doaj   +1 more source