Results 81 to 90 of about 11,417,388 (340)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Fast EXP3 Algorithms

CoRR
We point out that EXP3 can be implemented in constant time per round, propose more practical algorithms, and analyze the trade-offs between the regret bounds and time complexities of these algorithms.
Ryoma Sato, Shinji Ito
openaire   +2 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

The Fast Discrete Tchebichef Transform Algorithms for Short-Length Input Sequences

Signals
In this article, the fast algorithms for the discrete Tchebichef transform (DTT) are proposed for input sequences of lengths in the range from 3 to 8. At present, DTT is widely applied in signal processing, image compression, and video coding. The review
Aleksandr Cariow, Marina Polyakova
doaj   +1 more source

Fast calculation of scattering patterns using hypergeometric function algorithms

Scientific Reports, 2023
The scattering of light, X-rays, electrons or neutrons by matter is used widespread for structural characterization from atomic to macroscopic length scales.
Michael Wagener, Stephan Förster
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Empirical Evaluation of Typical Sparse Fast Fourier Transform Algorithms

IEEE Access, 2021
Computing the Sparse Fast Fourier Transform(sFFT) has emerged as a critical topic for a long time. The sFFT algorithms decrease the runtime and sampling complexity by taking advantage of the signal’s inherent characteristics that a large number of
Zhikang Jiang, Jie Chen, Bin Li
doaj   +1 more source

Fast algorithms for projected clustering

SIGMOD Conference, 1999
The clustering problem is well known in the database literature for its numerous applications in problems such as customer segmentation, classification and trend analysis.
C. Aggarwal, Cecilia M. Procopiuc, J. Wolf, Philip S. Yu, Jong Soo Park   +4 more
semanticscholar   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source