Results 71 to 80 of about 279,134 (312)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

A Comprehensive Review on DC Fast Charging Stations for Electric Vehicles: Standards, Power Conversion Technologies, Architectures, Energy Management, and Cybersecurity

IEEE Open Journal of Power Electronics
This paper aims to review the main research points regarding DC fast charging stations. At the beginning, the paper addresses an overview of DC fast charging standards, galvanic isolation, EV powertrain, and some examples of real DC fast chargers.
Gabriele Arena, Andrii Chub, Mykola Lukianov, Ryszard Strzelecki, Dmitri Vinnikov, Giovanni De Carne   +5 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

A Hierarchical Navigation Strategy of EV Fast Charging Based on Dynamic Scene

IEEE Access, 2019
With the development of the EV industry, the growing demand for EV fast charging load has brought enormous impact on the power system. Due to the unbalance of charging time distribution and the high power of EV fast charging, the difference between peak ...
Fangzhou Xia, Hongkun Chen, Lei Chen, Xinyu Qin   +3 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Multi-mode collaborative optimization of electric vehicle charging load characteristics in tourist cities: An Anshun case study

AIP Advances
This study developed an electricity consumption behavior model for electric vehicles during tourist and non-tourist seasons in Anhui based on the probability density algorithm. The daily load characteristics of three charging modes—regular charging, fast-
Weimin Wu, Zhaoqin Liu, Yun Wu, Wanjun Yan, Xiufan Yang   +4 more
doaj   +1 more source

Spatial and Electronic Manipulation of Silicon Nanocrystals by Atomic Force Microscopy [PDF]

, 1998
[As silicon-based devices shnnk, interest is increasing in fast, low-power devices sensitive to small numbers of electrons. Recent work suggests that MOS structures with large arrays of Si nanocrystals comprising a floating gate can be extremely fast ...
Atwater, Harry A., Bell, L. Douglas, Boer, Elizabeth A., Flagan, Richard C., Santamore, Deborah H., Vahala, Kerry J.   +5 more
core  

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Analysis and modelling of DC fast-charging profiles of heterogeneous EVs

Transportation Engineering
Electric vehicles (EVs) fast-charging is a crucial enabler for the smooth electrification of the private mobility. In the available literature, studies related to fast-charging have been mainly focusing on the optimal sizing/placement and/or operation of
Toni Simolin, Pertti Järventausta, Mario Paolone   +2 more
doaj   +1 more source