Results 121 to 130 of about 1,025,818 (339)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Nudging sustainable fashion choices: An experimental investigation on generation Z fashion consumers

Acta Psychologica
Despite the growing cognizance of Generation Z (Gen Z) fashion consumers about the externalities of fast fashion, an attitude-behaviour gap persists in their willingness to pay for sustainable fashion.
Anupama Prashar, Leena Ajit Kaushal
doaj   +1 more source

Comparative analysis: sustainable fashion vs. fast fashion

Revista Amazonia Investiga
Sustainable fashion is a philosophy centered on the ethical and environmentally responsible production of garments. However, currently prevailing in the market is a model known as fast fashion, which is characterized by mass production of low-quality garments at affordable prices.
Gisela Nuñez Martinez, Miguel Angel Martínez Cruz, Mauricio Chávez Pichardo, Alfredo Trejo Martínez, Tanya Arenas Reséndiz   +4 more
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Sustentabilidade na moda e o consumo consciente [PDF]

, 2014
ISBN 978-84-697-0700-5O presente artigo tem como objetivo fazer uma reflexão sobre a importância da sustentabilidade no âmbito da moda e o aparecimento de um novo consumidor, mais consciente e preocupado com os problemas da humanidade.
Araújo, Mariana Bezerra Moraes de, Broega, A. C., Ribeiro, Silvana Mota   +2 more
core  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Why should SME adopt IT enabled CRM strategy? [PDF]

Recent trends of fast adoption of CRM, whether as a philosophy, a strategy, an aid to the general marketing effort and mix, or merely as a fashion; as every body else is doing it; is driven by a clear acknowledgement and recognition that long-term ...
Constanta MIHAESCU, Ileana Gabriela NICULESCU-ARON, Miruna MAZURENCU MARINESCU   +2 more
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Análise das motivações do consumidor de fast-fashion

Revista de Administração IMED, 2016
O fast-fashion é um modelo de negócios utilizado do varejo de moda que abrange desde a criação do produto até sua produção e distribuição, com o objetivo responder rapidamente às constantes e cada vez mais frequentes mudanças de tendências de moda e de ...
Moema Pereira Nunes, Giuliana Almada da Silveira   +1 more
doaj