Results 61 to 70 of about 2,898,059 (299)

Multi-Layer Visualization of Mobile Mapping Data [PDF]

open access: yesISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2013
application various different visualization schemes are conceivable. This paper presents a multi-layer based visualization method, enabling fast data browsing of mobile mapping data.
D. Eggert, M. Sester
doaj   +1 more source

Fast generation of centroids for MAP-Elites

open access: yesProceedings of the Companion Conference on Genetic and Evolutionary Computation, 2023
The use of MAP-Elites in high-dimensional behavioral spaces requires a scalable method for dividing the space into regions of equal volume. So far, the recommended approach to generate these regions has been the Centroidal Voronoi Tesselation (CVT), but this algorithm has a significant computational cost (typically a few minutes for more than 50 ...
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Fast genetic mapping of complex traits in C. elegans using millions of individuals in bulk

open access: yesNature Communications, 2019
QTL mapping in multicellular animals usually requires generation, maintenance, and phenotyping large panels of recombinant individuals. Here, the authors develop ceX-QTL mapping, a method for fast genetic mapping via bulk selection on millions of unique ...
Alejandro Burga   +4 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Fast 3D Semantic Mapping in Road Scenes

open access: yesApplied Sciences, 2019
Fast 3D reconstruction with semantic information in road scenes is of great requirements for autonomous navigation. It involves issues of geometry and appearance in the field of computer vision.
Xuanpeng Li   +4 more
doaj   +1 more source

INDOOR MOBILE POSITIONING BASED ON LIDAR DATA AND CODED SEQUENCE PATTERN [PDF]

open access: yesThe International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2016
This paper proposed a coded sequence pattern for automatic matching of LiDAR point data, the methods including SIFT features, Otsu segmentation and Fast Hough transformation for the identification, positioning and interpret of the coded sequence patterns,
Z. Wang, B. Dong, D. Chen
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

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