Results 61 to 70 of about 6,488,308 (244)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Enhancing HEVC Efficiency: A Novel Approach to Intra-Mode Estimation Through Hadamard Cost Analysis

IEEE Access
In the realm of video coding, the quest for enhanced efficiency is unending. This study introduces a novel optimization in High Efficiency Video Coding (HEVC) by refining intra-mode estimation through Hadamard cost analysis.
Junaid Tariq, Imran Javed, Touseef Sadiq, Hameedur Rahman, Ashfaq Hussain Farooqi, Amir Ijaz   +5 more
doaj   +1 more source

Algorithm and Hardware Design of a Fast Intra Frame Mode Decision Module for H.264/AVC Encoders

International Journal of Reconfigurable Computing, 2012
In the rate-distortion optimization (RDO), the process of choosing the best prediction mode is performed through exhaustive executions of the whole encoding process, increasing significantly the encoder computational complexity.
Daniel Palomino, Guilherme Corrêa, Cláudio Diniz, Sergio Bampi, Luciano Agostini, Altamiro Susin   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

FAST video series

, 2014
Produced & directed a series of Families and Schools Together (FAST) videos. FAST has been recognized for its established track record of high retention rates (80%) of parents who are socially marginalized, and across languages, cultures, religion ...
McGorrian, T., School of Media and Performing Arts: Media   +1 more
core   +4 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Fast mode decision for scalable video coding over wireless network

, 2010
The scalable video coding H.264/SVC is the video coding standard which is an extension of H.264/AVC. Because of its scalability, H.264/SVC has gained a great interest in video transmission.
Priantoro, Akhmad Unggul, Gunawan, Teddy Surya, Maarif, Haris Al Qodri   +2 more
core  

Unimodal Model-Based Inter Mode Decision for High Efficiency Video Coding

IEEE Access, 2019
In this paper, a fast inter mode decision algorithm, called the unimodal model-based inter mode decision (UMIMD), is proposed for the latest video coding standard, the high-efficiency video coding. Through extensive simulations, it has been observed that
Huanqiang Zeng, Wenjie Xiang, Jing Chen, Canhui Cai, Zhangkai Ni, Kai-Kuang Ma   +5 more
doaj   +1 more source