Results 71 to 80 of about 495 (240)

Continuum Mechanics Modeling of Flexible Spring Joints in Surgical Robots

Advanced Robotics Research, EarlyView.
A new mechanical model of a tendon‐actuated helical extension spring joint in surgical robots is built using Cosserat rod theory. The model can implicitly handle the unknown contacts between adjacent coils and numerically predict spring shapes from straight to significantly bent under actuation forces.
Botian Sun, Liang Zhang, Jianwen Zeng, Xuefeng Wang   +3 more
wiley   +1 more source

Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development

Advanced Science, EarlyView.
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen, Zichen Liu, Mengyi Wei, Qian Li, Liang Wu, Kunyuan Yu, Yanhong Xu, Dainan Yu, Wenwu Ma, Hongmei Wang, Ng Shyh‐Chang, Jinglei Zhai   +11 more
wiley   +1 more source

Evaluating the Utilities of Foundation Models in Single‐Cell Data Analysis

Advanced Science, EarlyView.
This study delivers the first systematic, task‐level evaluation of single‐cell foundation models across eight core analytical tasks. By benchmarking 10 leading models with the scEval framework, it reveals where foundation models truly add value, where task‐specific methods still dominate, and provides concrete, reproducible guidelines to steer the next
Tianyu Liu, Kexing Li, Yuge Wang, Hongyu Li, Hongyu Zhao   +4 more
wiley   +1 more source

A Guide for Spatial Omics Technologies: Innovation, Evaluation, and Application

Advanced Science, EarlyView.
This review presents a strategy‐centric framework for spatial omics technologies, organizing methods by how spatial information is experimentally encoded. It compares key performance trade‐offs across sequencing‐ and imaging‐based approaches, examines computational and practical limitations, and highlights biomedical applications. The analysis provides
Xiaofeng Wu, Weize Xu, Da Lin, Leqiang Sun, Jinxia Dai, Gang Cao   +5 more
wiley   +1 more source

Quantifying Advantages of a Moving Mesh in Nuclear Hydrodynamics

The Astrophysical Journal
Many astrophysical explosions, such as type Ia supernovae, classical novae, and X-ray bursts, are dominated by thermonuclear runaway. To model these processes accurately, one must evolve nuclear reactions concurrently with hydrodynamics.
Dillon L. Hasenour, Paul C. Duffell
doaj   +1 more source

Minute-Cadence Observations of the LAMOST Fields with the TMTS: IV—Catalog of Cataclysmic Variables from the First 3-yr Survey

Universe
The Tsinghua University–Ma Huateng Telescopes for Survey (TMTS) started to monitor the LAMOST plates in 2020, leading to the discovery of numerous short-period eclipsing binaries, peculiar pulsators, flare stars, and other variable objects.
Qichun Liu, Jie Lin, Xiaofeng Wang, Zhibin Dai, Yongkang Sun, Gaobo Xi, Jun Mo, Jialian Liu, Shengyu Yan, Alexei V. Filippenko, Thomas G. Brink, Yi Yang, Kishore C. Patra, Yongzhi Cai, Zhihao Chen, Liyang Chen, Fangzhou Guo, Xiaojun Jiang, Gaici Li, Wenxiong Li, Weili Lin, Cheng Miao, Xiaoran Ma, Haowei Peng, Qiqi Xia, Danfeng Xiang, Jicheng Zhang   +26 more
doaj   +1 more source

Dust and Coronal Lines in the Very Fast Nova V2361 Cygni

Research Notes of the AAS
Abstract “Very fast” novae, with their high ejection velocities, smaller ejecta masses, high photospheric temperatures, and rapidly changing conditions are generally inhospitable to the formation and survival of dust. Here we present infrared spectra from multiple epochs of a rare exception, the nova V2361 Cygni. With its time to decline
Richard J. Rudy, Ray W. Russell, David K. Lynch, R. C. Puetter   +3 more
openaire   +1 more source

Pancancer Fine‐Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study identifies mutation‐intolerant genes (MIGs), which are mutationally constrained in tumors despite normal‐tissue variability. Using miDriver, the authors pinpoint MIGs essential for tumor‐intrinsic fitness and immune evasion. Focusing on CHEK1, they show it drives tumor fitness and sculpts an immunosuppressive niche via the MIF–CD74 axis ...
Tao Wang, Hongyu Zhao, Xiaojie Sun, Yuqi Ding, Zhipeng Zhu, Xiaotong Yu, Rongyi Zhu, Dan Wang, Kailong Li, Yang Liu, Li‐Bin Wang, Xiaolu Zhao, Baojun Suo, Hongsen Bi, Peipei Zhang, Tong Liu, Fengbiao Mao   +16 more
wiley   +1 more source

Hydro-radiative Simulations, Analytical Modeling, and Laboratory Scaling of Complex Shock Structures in Novae Ejecta

The Astrophysical Journal
Radiative shocks are fundamental in astrophysical phenomena, particularly in novae ejecta, where interactions between fast and slow outflows lead to double-shock structures (DSSs).
Léa Dollerschell, Lucile Van Box Som, Emeric Falize   +2 more
doaj   +1 more source

ZSL Orchestrates Synaptonemal Complex Assembly as a Central Region Scaffold to Ensure Synapsis Fidelity and Crossover Control in Polyploid Meiosis

Advanced Science, EarlyView.
A central molecular adaptor, ZSL, is identified that links transverse filaments ZYP1 to central element SCEP1/2 to drive synaptonemal complex assembly in Brassica napus. Loss of ZSL abolishes synaptonemal complex formation, disrupts meiotic chromosome segregation, and markedly increases crossovers, providing mechanistic insight into meiotic fidelity ...
Miaowei Geng, Shaochen Jia, Fei Cao, Cuiping Liu, Heshuang Zhang, Gang Xu, Jixin Zhuang, Yashi Zhang, Can Liu, Yuhang Zhao, Zilin Guo, Xinjie Yuan, Jiaqing Yang, Lei Chu, Bowei Cai, Hu Zhao, Chao Yang   +16 more
wiley   +1 more source