Results 111 to 120 of about 805,683 (297)

STEPPING INDUCTOR FOR FAST TRANSIENT RESPONSE OF SWITCHING CONVERTER [PDF]

open access: yes, 2004
A fast transient response converter is disclosed which makes use of stepping inductor in a switching converter to speed up output voltage response under fast transient condition. The inductive element in a switching converter is replaced by two series or

core  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Design of a novel fast turn-off circuit of transient electromagnetic transmitter

open access: yesGong-kuang zidonghua, 2016
In view of problem that turn-off time of emission current of transient electromagnetic transmitter is overlong caused by parasitic inductance of the transmitter coils, a novel fast turn-off circuit was designed. During the decline of transmitting current,
WANG Guangjun, MIN Deshun
doaj   +1 more source

Swift/XRT monitoring of the Supergiant Fast X-ray Transient IGR J18483-0311 for an entire orbital period

open access: yes, 2009
IGR J18483-0311 is an X-ray pulsar with transient X-ray activity, belonging to the new class of High Mass X-ray Binaries called Supergiant Fast X-ray Transients.
Bazzano, A.   +11 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Mitigation of Transient Overvoltages Generated Due to Switching Operations and Lightning in Gas-insulated Substation (GIS) Without Extra Limiter

open access: yesIranian Journal of Electrical and Electronic Engineering, 2011
Gas-insulated substations (GIS) have different specifications in proportion to air-insulated substations. Transformer failures related to lightning and switching are often reported in the gas insulated substation (GIS).
A. Tavakoli, A. Gholami
doaj  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

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