Results 81 to 90 of about 800,531 (298)

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Self-healing fuse [PDF]

open access: yes, 1974
Fast-acting current limiting device provides current overload protection for vulnerable circuit elements and then re-establishes conduction path within milliseconds. Fuse can also perform as fast-acting switch to clear transient circuit overloads.
Harris, L. P.   +2 more
core   +1 more source

Transient absorption and photocurrent microscopy show hot electron supercollisions describe the rate-limiting relaxation step in graphene

open access: yes, 2013
Using transient absorption (TA) microscopy as a hot electron thermometer we show disorder-assisted acoustic-phonon supercollisions (SCs) best describes the rate-limiting relaxation step in graphene over a wide range of lattice temperatures ($T_l=$5-300 K)
Graham, Matt W.   +5 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Resistojet research and development, phase ii second quarterly progress report, 1 oct. - 31 dec. 1964 [PDF]

open access: yes
Transient propulsion performance of 10 watt fast heating resistojet ...
John, R. R., Morgan, D.
core   +1 more source

STEPPING INDUCTOR FOR FAST TRANSIENT RESPONSE OF SWITCHING CONVERTER [PDF]

open access: yes, 2005
A fast transient response converter is disclosed which makes use of stepping inductor in a switching converter to speed up output voltage response under fast transient condition. The inductive element in a switching converter is replaced by two series or

core  

Transient outburst mechanisms in Supergiant Fast X-ray Transients [PDF]

open access: yesAdvances in Space Research, 2009
Invited talk at the 37th COSPAR Scientific Assembly, held on 13-20 July 2008, in Montreal, Canada. Symposium E, session 11. Accepted for publication in Advances in Space Research.
openaire   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Fast excitation structure for improving the transient time of magnetic controlled reactors

open access: yesInternational Journal of Electrical Power & Energy Systems
With the increasing proportion of renewable energy usage, the randomness and volatility of renewable energy have led to a corresponding increase in the demand for reactive power regulation in the power system.
Xiyu Yin   +7 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

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