Results 91 to 100 of about 7,052,544 (291)

Experimental investigation into transient operating strategies of a turbocharged lean-burn hydrogen ICE and comparison to diesel performance

Automotive and Engine Technology
Hydrogen fuelled internal combustion engines (H2-ICEs) are a promising zero-carbon propulsion solution. Although their steady-state performance has been investigated widely, sufficient transient performance is still challenging, especially for lean-burn,
Paul Christoforetti, Peter Kappacher, Eberhard Schutting, Helmut Eichlseder   +3 more
doaj   +1 more source

Stepping inductor for fast transient response of switching converter [PDF]

, 2006
A fast transient response converter is disclosed which makes use of stepping inductor in a switching converter to speed up output voltage response under fast transient condition. The inductive element in a switching converter is replaced by two series or

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PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Immediate early splicing controls translation in activated T-cells and is mediated by hnRNPC2 phosphorylation

The EMBO Journal
The fast and transient induction of immediate early genes orchestrates the cellular response to various stimuli. These stimuli trigger phosphorylation cascades that promote immediate early gene transcription independent of de novo protein synthesis. Here
Mateusz Dróżdż, Luíza Zuvanov, Gopika Sasikumar, Debojit Bose, Franziska Bruening, Maria S Robles, Marco Preußner, Markus Wahl, Florian Heyd   +8 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Stepping inductor for fast transient response of switching converter [PDF]

, 2009
A fast transient response converter is disclosed which makes use of stepping inductor in a switching converter to speed up output voltage response under fast transient condition. The inductive element in a switching converter is replaced by two series or

core  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Study on 3D forward modeling of transient electromagnetic method for rough media

Meikuang Anquan
To investigate the influence of microscopic spatial structures such as pores and fractures inside media on the diffusion law of transient electromagnetic fields, a 3D forward modeling method for transient electromagnetics applicable to rough media is ...
Zhenglei Wu, Jianhui Li, Weihua Yao
doaj   +1 more source

Framework for Decision Making in the Field of Environment and Health [PDF]

, 2012
Zie ook "Nuchter omgaan met risico's" 251701047In mei 2002 hebben de ministeries van VROM en VWS het Actieprogramma Gezondheid en Milieu aan de Tweede Kamer gepresenteerd.
Fast T, Bruggen M van
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