Results 101 to 110 of about 7,052,544 (291)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

A Comparator-Less Buck Converter with Fast Transient Response Using a Reactive Ramp Generator

Energies
This paper introduces a voltage-mode DC-DC buck converter designed to address the challenges of high-frequency operation. The proposed comparator-less Reactive Ramp Generator (RRG) topology mitigates the issues associated with comparator delays ...
Young-Kyu Kim, Chung-Hee Jang, Dong-Hyun Shin, Kwang-Hyun Baek   +3 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

A push–pull FVF LDO with full‐spectrum PSR and fast transient response

Electronics Letters
A push–pull low‐dropout regulator based on flipped voltage follower is proposed and designed in 65 nm CMOS, which has a push‐current mode and a pull‐current one.
Heng Zheng, Baixin Liu, Chen Wang, Xukun Wang, Bo Zhou   +4 more
doaj   +1 more source

Active Transient Voltage Compensator for Fast Transient Response Improvement [PDF]

, 2007
A direct current to direct current (DC-to-DC) converter having an active transient voltage compensator (ATVC) coupled with the DC-to-DC converter output terminal to improve a fast transient response of the DC-to-DC converter. The active transient voltage
Chickamenahalli, Shamala, Stanford, Edward, Wang, Xiangcheng, Batarseh, Issa   +3 more
core  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Immersion and Invariance Adaptive Integral Sliding Mode-Based Second-Order Prescribed Performance Control of Flexible Joint Manipulators

IEEE Access
This paper proposes an immersion and invariance (I&I) adaptive integral sliding mode-based second-order prescribed performance control (ISM-SOPPC) framework for flexible joint manipulators (FJMs) subject to dynamic uncertainties and external ...
Youngwook Jung, Junseok Boo, Kangmin Jo, Dongkyoung Chwa   +3 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Voltage injection switching inductor (VISI) method for fast transient response in switch mode power supplies

, 2008
A fast transient response to a step load change is very essential in a switch mode power supply. The transient response can be improved by means of feedback control method.
Hussain S. Athab, Jegandren, J., Gobbi, R., J. Jegandren., R. Gobbi., Athab, Hussain S.   +5 more
core   +1 more source