Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Low testosterone level increases fasting blood glucose level in adult males [PDF]
Universa Medicina, 2012 Background Total testosterone (TT) levels in males decrease with age. There has been a vigorous debate on the extent to which low testosterone causally contributes to diabetes and its complications.
Suweino, ML Edy Parwanto, David Tjahjadi
doaj
A Hepatocyte FOXN3-α Cell Glucagon Axis Regulates Fasting Glucose
Cell Reports, 2018 Summary: The common genetic variation at rs8004664 in the FOXN3 gene is independently and significantly associated with fasting blood glucose, but not insulin, in non-diabetic humans.
Santhosh Karanth +10 more
doaj +1 more source
Impact of prenatal famine exposure on adulthood fasting blood glucose level
Scientific Reports, 2022 In the past decade, in low-income countries, there have been a rapid rise in prevalence of diabetes among adult population. Hence, understanding the context specific drivers of this change including the impacts of childhood nutrition adversaries on adult
Kalkidan Hassen Abate +4 more
doaj +1 more source
Panax ginseng has no effect on indices of glucose regulation following acute or chronic ingestion in healthy volunteers [PDF]
, 2009 In the absence of effective pharmacotherapy for diabetes there has been an increase in the use of, and research into, alternative treatment strategies. These include exercise, dietary interventions and the use of supplements including extracts of ginseng.
Andrew B. Scholey +8 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Postprandial Blood Glucose can be less than Fasting Blood Glucose and this is not a Laboratory Error
Journal of Nepal Medical Association, 2019 Higher fasting blood glucose level than post prandial level can be seen in variety of conditions in both normal population and diabetics. Various modifiable factors along with underlying condition of patient behind such laboratory picture are discussed ...
Vivek Pant +2 more
doaj +1 more source
Development and Validation of a Tool for Assessing Glucose Impairment in Adolescents [PDF]
, 2012 INTRODUCTION: Childhood obesity is associated with an increased risk for type 2 diabetes. Early identification of adolescents at risk for impaired fasting blood glucose may lead to earlier and more comprehensive evaluation and intervention.
Collier, David N. +5 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Are glucose profiles well-controlled within the targets recommended by the International Diabetes Federation in type 2 diabetes? A meta-analysis of results from continuous glucose monitoring based studies [PDF]
, 2018 AIMS: To assess continuous glucose monitoring (CGM) derived intra-day glucose profiles using global guideline for type 2 diabetes recommended by the International Diabetes Federation (IDF).
Chastin, Sebastien F.M. +4 more
core +2 more sources