Results 201 to 210 of about 5,617,639 (311)

Is metabolically healthy obesity shaped by inflammation, gender differences, and fat distribution? [PDF]

World J Cardiol
Ramoni D, Liberale L, Carbone F, Montecucco F.   +3 more
europepmc   +1 more source

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, EarlyView.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source

Efficacy of Weight-Lowering Agents on Fat Distribution: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials. [PDF]

Obes Rev
Qiao X, Wang W, Cao J, Guo L, Pan Q.
europepmc   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Association of PREVENT risk model with body fat distribution and subclinical left ventricular dysfunction. [PDF]

Am J Prev Cardiol
Hirose K, Nakanishi K, Daimon M, Sawada N, Konoma S, Kobayashi S, Seki H, Yoshida Y, Hirokawa M, Nakao T, Morita H, Di Tullio MR, Homma S, Kurano M, Takeda N.   +14 more
europepmc   +1 more source

m6A‐Driven Pexophagy Triggers Placental Ferroptosis to Impair Fetal Growth Upon Environmental Stress

Advanced Science, EarlyView.
Prenatal environmental stress exposure promotes m6A modification to drive PEX2‐dependent pexophagy, thereby causing placental ferroptosis and FGR. ABSTRACT The role and underlying mechanisms of placental ferroptosis in fetal growth restriction (FGR) induced by environmental stress remain poorly understood.
Xin‐Xin Zhang, Ye‐Xin Luo, Cheng‐Fang Sun, Rui Pan, Yu‐Xi Wu, Zhi Yuan, Xin‐Run Wang, Xu‐Dong Zhang, Lan‐Lan Wu, Xiang‐Yu Yao, Zhan‐Dong Song, Wei Chang, Tian Wei, Pan‐Yuan Cai, Tian‐Ci Zhang, Yong‐Wei Xiong, De‐Xiang Xu, Hua Wang, Hua‐Long Zhu   +18 more
wiley   +1 more source

Causal Effects of Childhood BMI on Regional Fat Distribution in Adults: A Mendelian Randomisation and Proteomic Mediation Analysis

Hayes B, Hazelwood E, Power G, Gilbody J, Pournaras D, Freisling H, Richmond R, Vincent E.   +7 more
europepmc   +1 more source

Association of the TyG index and its body fat distribution composites with CHD and MACE risk in adults with OSAHS: incremental discrimination and exploratory mediation analysis. [PDF]

Front Endocrinol (Lausanne)
Liang Z, Zhu X, Chen Y, Maimaitimin A, Nihemaiti N, Shata G, Maihemutijiang R.   +6 more
europepmc   +1 more source