Results 81 to 90 of about 5,617,639 (311)

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Body fat percent and distribution

, 2019
The role of body fat and its distribution in sexual selection.
Esther M. Cohen-Tovée (17209441), Martin Tovee (17168797)   +1 more
core   +2 more sources

Deep phenotyping in zebrafish reveals genetic and diet-induced adiposity changes that may inform disease risk

Journal of Lipid Research, 2018
The regional distribution of adipose tissues is implicated in a wide range of diseases. For example, proportional increases in visceral adipose tissue increase the risk for insulin resistance, diabetes, and CVD.
JamesE.N. Minchin, Catherine M. Scahill, Nicole Staudt, Elisabeth M. Busch-Nentwich, John F. Rawls   +4 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Body fat measurement in Indian men: Comparison of three methods based on a two-compartment model. [PDF]

, 2005
Obesity is a major risk factor for diabetes and related disorders. The current classification of obesity is based on body mass index (BMI, kg/m(2)), which is a surrogate for the total body fat.
Sayyad, MG, Lubree, HG, Yudkin, JS, M G Sayyad, Bhat, DS, C S Yajnik, Chougule, SD, Kurpad, AV, P S Shetty, H G Lubree, A V Kurpad, Shetty, PS, K N Raut, Yajnik, CS, Rege, SS, S D Chougule, J S Yudkin, D S Bhat, Raut, KN, S S Rege   +19 more
core   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Genetic Studies Reveal Specific Genetic Variants and Disease Risks Associated With Fat Distribution Across Anatomical Sites [PDF]

Objective: To investigate the genetic determinants of fat distribution across anatomical sites and their implications for health outcomes. Methods: We analyzed neck-to-knee MRI data from the UK Biobank (n = 37,589) to measure fat at various locations ...
Chiemela S. Odoemelam, Madeleine Cule, Naz, Afreen, Marjola Thanaj, Cule, Madeleine, Elena P. Sorokin, Sattar, Naveed, Hanieh Yaghootkar, Louise Thomas, E., E. Louise Thomas, Thanaj, Marjola, Bell, Jimmy D., Sorokin, Elena P., Whitcher, Brandon, Naveed Sattar, Afreen Naz, Brandon Whitcher, Ahmed, Altayeb, Jimmy D. Bell, Thomas, E. Louise, Yaghootkar, Hanieh, Odoemelam, Chiemela S., Altayeb Ahmed, Odoemelam, C.S., Thanaj, M., Sattar, N., Sorokin, E., Cule, M., Yaghootkar, H., Thomas, E.L., Bell, J.D., Whitcher, B., Ahmed, A., Odoemelam, C., Naz, A.   +34 more
core   +1 more source

Genetic markers of obesity risk: stronger associations with body composition in overweight compared to normal-weight children. [PDF]

, 2011
Genetic factors are important determinants of overweight. We examined whether there are differential effect sizes depending on children's body composition.
Kries, Rüdiger von, Andrew R. Ness, Rüdiger von Kries, von Kries Rüdiger, Ong Ken K., Ong, Ken K., Beyerlein, Andreas, Andreas Beyerlein, Andrew R Ness, Ong Ken, K, Ken K. Ong, Ness, Andrew R., Ken K Ong, Bayerlain, Andreas, Beyerlein Andreas, Ness Andrew R., Von Kries, Rudiger, Ness, A   +17 more
core   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source