Results 161 to 170 of about 641,203 (266)

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Association Between Relative Fat Mass and Risk of Cognitive Impairment: The Role of Social Determinants of Health. [PDF]

Actas Esp Psiquiatr
Wang D, Liang H, Gan Z, Zhang J, Wu J.
europepmc   +1 more source

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

Association between fat mass index and depressive symptoms in U.S. adults: A cross-sectional analysis of NHANES 2011-2016. [PDF]

Medicine (Baltimore)
Wu H, Yang S, Chen C, Wang X, Chen W, Ge F.   +5 more
europepmc   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Waist Circumference, Relative Fat Mass Index, and BMI as Classifiers of Diabetes Status: A Comparative, Cross-sectional Analysis in 82 Low- and Middle-Income Countries. [PDF]

Diabetes Care
Seiglie JA, Seuring T, Teufel F, Marcus ME, Theilmann M, Geldsetzer P, Agoudavi K, Andall-Brereton G, Aryal KK, Wilfried Bicaba B, Bovet P, Campos Caldeira Brant L, Brian G, Damasceno A, Dorobantu M, Farzadfar F, Gathecha G, Golestani A, Singh Gurung M, Heidari-Foroozan M, Houehanou C, Houinato D, Hwalla N, Jorgensen J, Mwangi KJ, Kagaruki GB, Karki KB, Lunet N, Malta DC, Martins JS, Msaidie M, Mwalim O, Norov B, Quesnel-Crooks S, Saeedi Moghaddam S, Sibai A, Sturua L, Tsabedze L, Stanford Wesseh C, Wong McClure R, Gune Yoo S, Atun R, Davies JI, Vollmer S, Bärnighausen TW, Flood D, Woolcott OO, Manne-Goehler J.   +47 more
europepmc   +1 more source

Fat mass but not muscle mass linked to OA risk [PDF]

Nature Reviews Rheumatology, 2018
openaire   +2 more sources

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

Cross-sectional association between relative fat mass and abdominal aortic calcification among US adults: The NHANES 2013 to 2014. [PDF]

Medicine (Baltimore)
Fang L.
europepmc   +1 more source

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source