Results 231 to 240 of about 1,316,652 (307)

Impact of Semaglutide on fat mass, lean mass and muscle function in patients with obesity: The SEMALEAN study. [PDF]

Diabetes Obes Metab
Alissou M, Demangeat T, Folope V, Van Elslande H, Lelandais H, Blanchemaison J, Cailleaux PE, Guney S, Aupetit A, Aubourg A, Rapp C, Petit A, Godin M, Vignal L, Grigioni S, Déchelotte P, Colange G, Coëffier M, Achamrah N.   +18 more
europepmc   +1 more source

Relationships Between Lean Body Mass and Fat Mass with Physical Fitness Performance in Deputy Sheriff Recruits [PDF]

, 2018
Carlock, Blake, Dawes, Jay J., Dulla, Joseph, Lockie, Robert G., Moreno, Matthew R., Orr, Rob Marc   +5 more
core  

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Physical fitness is associated with fat mass and muscle mass in Chinese preschoolers. [PDF]

BMC Public Health
Guo J, Lu Z, Bao Y, Chang J, Zhang H, Wang F, Chen W, Shi J, Wang M, Liu J, Liu C, Wang S, Wu J, Guan H, Zhang T.   +14 more
europepmc   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Fat mass and obesity-associated protein downregulation enhances N6-methyladenosine methylation and drives ovarian cancer progression. [PDF]

J Cell Commun Signal
Wang X, Wu D, Li C, Du X.
europepmc   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Association between low-density lipoprotein and structural changes in the knee joint of patients with symptomatic osteoarthritis is mediated by relative fat mass. [PDF]

Eur J Med Res
Li Q, Bo K, Shen C.
europepmc   +1 more source

NUP85 Mediates Endoplasmic Reticulum Stress through the USP47/ASK1 Signaling Pathway to Regulate the Progression of Liver Fibrosis

Advanced Science, EarlyView.
In the present study, we have demonstrated that the NUP85‐USP47‐ASK1 signaling pathway may have regulated the progression of liver fibrosis through modulating ERS. Additionally, we have developed a CREKA‐coupled liposome to target delivery of MV, a pharmacological inhibitor of NUP85, to activated HSCs, thereby attenuating liver fibrosis. ABSTRACT Liver
Dashuai Yang, Haoran Yang, Linxin Pan, Chang Tian, Fucheng Zuo, Shilei Huang, Xianrui Li, Ming Chen, Cheng Qian, Jie Wang, Zhaolin Chen, Tao Xu   +11 more
wiley   +1 more source

Fat mass in postmenopausal women with osteoporosis is associated with cognitive function. [PDF]

Sci Rep
Zhang D, Zhu Z, Xue L, Zheng Y, Li X, Xu M, Xie X, Wang Y.   +7 more
europepmc   +1 more source