Results 51 to 60 of about 595,756 (311)

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Fat and fat-free mass as important determinants of body composition assessment in relation to sarcopenic obesity

Roczniki Panstwowego Zakladu Higieny, 2023
Background. Fat and fat-free/muscle mass and their ratio reflecting the possible presence of obesity or sarcopenic obesity are important in assessing body composition. Objective.
Martina Gažarová, Maroš Bihari, Jaroslav Šoltís   +2 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Ratio of fat-free mass to fat mass is associated with physical performance in patients with type 2 diabetes mellitus

Frontiers in Endocrinology
BackgroundThe ratio of fat-free mass (FFM) to fat mass (FM) is a key indicator of body composition. Evidence suggests that the FFM/FM ratio is more reliable than body mass index in predicting functional outcomes in older adults with prefrailty ...
Jui-Hsiang Sung, Fu-Shun Ko, Tsung-Hui Wu, Tsung-Hui Wu, Shiow-Chwen Tsai, Chii-Min Hwu, Chii-Min Hwu, Guan-Yu Su, Guan-Yu Su   +8 more
doaj   +1 more source

Dietary Fiber Intake Is Related to Skeletal Muscle Mass, Body Fat Mass, and Muscle-to-Fat Ratio Among People With Type 2 Diabetes: A Cross-Sectional Study

Frontiers in Nutrition, 2022
ObjectivesTo investigate the relationship between dietary fiber intake and skeletal muscle mass, body fat mass, and muscle-to-fat ratio (MFR) among men and women with type 2 diabetes (T2D).MethodsThis cross-sectional study involved 260 men and 200 women ...
Fuyuko Takahashi, Yoshitaka Hashimoto, Ayumi Kaji, Ryosuke Sakai, Yuka Kawate, Takuro Okamura, Hiroshi Okada, Noriyuki Kitagawa, Noriyuki Kitagawa, Naoko Nakanishi, Saori Majima, Takafumi Osaka, Takafumi Senmaru, Emi Ushigome, Mai Asano, Masahide Hamaguchi, Masahiro Yamazaki, Michiaki Fukui   +17 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Regular smoking of male ancestors in adolescence and fat and lean mass in young adult grandchildren and great-grandchildren [PDF]

, 2022
Steven Gregory, Matthew Suderman, Kate Northstone, Marcus Pembrey, Sarah Watkins, Yasmin Iles‐Caven, Jean Golding   +6 more
openalex   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Longitudinal association of adiposity with wheezing and atopy at 22 years: the 1993 Birth Cohort, Pelotas, Brazil

Journal of Asthma and Allergy, 2018
Ana Maria Baptista Menezes,1 Paula Duarte de Oliveira,1 Cauane Blumenberg,1 Efrain Sanchez-Angarita,2 Gloria Isabel Niño-Cruz,1 Ignacio Zabert,3 Janaina Calu Costa,1 Luiza Isnardi Cardoso Ricardo,1 Rafaela Costa Martins,1 Fernando César ...
Menezes AMB, Oliveira PD, Blumenberg C, Sanchez-Angarita E, Niño-Cruz GI, Zabert I, Costa JC, Ricardo LIC, Martins RC, Wehrmeister FC   +9 more
doaj  

Trunk fat and leg fat in relation to free triiodothyronine in euthyroid postmenopausal women

Endocrine Connections, 2019
Background: A high level of free triiodothyronine (FT3) within the referen ce range may be a potential metabolic risk marker. However, the relationship between different fat depots and FT3 has remained unclear.
Xiaomin Nie, Yiting Xu, Xiaojing Ma, Yun Shen, Yufei Wang, Yuqian Bao   +5 more
doaj   +1 more source