Results 71 to 80 of about 1,316,652 (307)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The impact of body composition and fat distribution on blood pressure in young and middle-aged adults

Frontiers in Nutrition, 2022
BackgroundThe relative contributions of each component of body composition to blood pressure (BP) remain unclear.ObjectiveWe aimed to comprehensively investigate the impact of body composition and fat distribution on BP and quantify their relative ...
Song Zhao, Jiamin Tang, Yifan Zhao, Chong Xu, Yawei Xu, Shikai Yu, Yi Zhang   +6 more
doaj   +1 more source

Control of bone and fat mass by oxytocin [PDF]

Hormone Molecular Biology and Clinical Investigation, 2016
Abstract Osteoporosis and overweight/obesity constitute major worldwide public health burdens. Aging is associated with a decrease in hormonal secretion, lean mass and bone mass, and an increase in fat accumulation. It is established that both obesity and osteoporosis are affected by genetic and environmental factors, bone remodeling ...
Amri, Ez-Zoubir, Pisani, Didier
openaire   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Dietary Fiber Intake Is Related to Skeletal Muscle Mass, Body Fat Mass, and Muscle-to-Fat Ratio Among People With Type 2 Diabetes: A Cross-Sectional Study

Frontiers in Nutrition, 2022
ObjectivesTo investigate the relationship between dietary fiber intake and skeletal muscle mass, body fat mass, and muscle-to-fat ratio (MFR) among men and women with type 2 diabetes (T2D).MethodsThis cross-sectional study involved 260 men and 200 women ...
Fuyuko Takahashi, Yoshitaka Hashimoto, Ayumi Kaji, Ryosuke Sakai, Yuka Kawate, Takuro Okamura, Hiroshi Okada, Noriyuki Kitagawa, Noriyuki Kitagawa, Naoko Nakanishi, Saori Majima, Takafumi Osaka, Takafumi Senmaru, Emi Ushigome, Mai Asano, Masahide Hamaguchi, Masahiro Yamazaki, Michiaki Fukui   +17 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Ratio of fat-free mass to fat mass is associated with physical performance in patients with type 2 diabetes mellitus

Frontiers in Endocrinology
BackgroundThe ratio of fat-free mass (FFM) to fat mass (FM) is a key indicator of body composition. Evidence suggests that the FFM/FM ratio is more reliable than body mass index in predicting functional outcomes in older adults with prefrailty ...
Jui-Hsiang Sung, Fu-Shun Ko, Tsung-Hui Wu, Tsung-Hui Wu, Shiow-Chwen Tsai, Chii-Min Hwu, Chii-Min Hwu, Guan-Yu Su, Guan-Yu Su   +8 more
doaj   +1 more source

Trunk fat and leg fat in relation to free triiodothyronine in euthyroid postmenopausal women

Endocrine Connections, 2019
Background: A high level of free triiodothyronine (FT3) within the referen ce range may be a potential metabolic risk marker. However, the relationship between different fat depots and FT3 has remained unclear.
Xiaomin Nie, Yiting Xu, Xiaojing Ma, Yun Shen, Yufei Wang, Yuqian Bao   +5 more
doaj   +1 more source

Relation of C-reactive protein to body fat distribution and features of the metabolic syndrome in Europeans and South Asians.

, 2001
OBJECTIVE: To investigate the association between circulating C-reactive protein (CRP) concentrations and indices of body fat distribution and the insulin resistance syndrome in South Asians and Europeans. DESIGN: : Cross-sectional study.
NG Forouhi, N Sattar, PM McKeigue, PM Ridker, PM Ridker, F Haverkate, W Koenig, MA Mendall, RP Tracy, JC Pickup, JS Yudkin, A Festa, PM McKeigue, PM McKeigue, PM McKeigue, JC Seidell, JR Patsch, J Highton, JP Després, AS Greenberg, T Chajek-Shaul, P Bjorntorp, P Ebeling, U Saxena   +23 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source