Results 81 to 90 of about 4,193,745 (307)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Body composition and appetite : fat-free mass (but not fat mass or BMI) is positively associated with self-determined meal size and daily energy intake in humans [PDF]

, 2011
The idea of body weight regulation implies that a biological mechanism exerts control over energy expenditure and food intake. This is a central tenet of energy homeostasis.
Finlayson, Graham, Finlayson, G, King, NA, Naslund, Erik, Mark Hopkins, Naslund, E, Caudwell, P, Blundell, JE, Gibbons, C, Hopkins, M, Hopkins, Mark, Graham Finlayson, Blundell, John E., Phillipa Caudwell, Gibbons, Catherine, John E. Blundell, King, Neil A., Catherine Gibbons, Erik Näslund, Neil A. King, Caudwell, Phillipa   +20 more
core   +2 more sources

Ratio of fat-free mass to fat mass is associated with physical performance in patients with type 2 diabetes mellitus

Frontiers in Endocrinology
BackgroundThe ratio of fat-free mass (FFM) to fat mass (FM) is a key indicator of body composition. Evidence suggests that the FFM/FM ratio is more reliable than body mass index in predicting functional outcomes in older adults with prefrailty ...
Jui-Hsiang Sung, Fu-Shun Ko, Tsung-Hui Wu, Tsung-Hui Wu, Shiow-Chwen Tsai, Chii-Min Hwu, Chii-Min Hwu, Guan-Yu Su, Guan-Yu Su   +8 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Trunk fat and leg fat in relation to free triiodothyronine in euthyroid postmenopausal women

Endocrine Connections, 2019
Background: A high level of free triiodothyronine (FT3) within the referen ce range may be a potential metabolic risk marker. However, the relationship between different fat depots and FT3 has remained unclear.
Xiaomin Nie, Yiting Xu, Xiaojing Ma, Yun Shen, Yufei Wang, Yuqian Bao   +5 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

High fat intake leads to acute postprandial exposure to circulating endotoxin in type 2 diabetic subjects [PDF]

, 2012
OBJECTIVE-To evaluate the changes in circulating endotoxin after a high-saturated fat meal to determine whether these effects depend on metabolic disease state.
Varma, M.C., Saravanan, Ponnusamy, Saravanan, P., Tripathi, Gyanendra, Kumar, Sudhesh, Sabico, Shaun, Sabico, S., O'Hare, J.P., McTernan, P. G., Harte, A. L., Varma, Madhusudhan C., Ceriello, A., Al-Attas, Omar S., McTernan, P.G., Al-Attas, O.S., Al-Daghri, Nasser M., Ceriello, Antonio, McGee, K. C., O'Hare, J. Paul, McGee, K.M., Al-Daghri, N.M., Kumar, S., Harte, A.L., Tripathi, G.   +23 more
core   +1 more source

Body mass index: a measure of fatness or leanness?

, 1995
The relationship between body fat and stature-adjusted weight indices was explored. Assuming the term height’ is a valid indicator of a subject’s lean body mass, heighplweight was shown to be an accurate measure of percentage lean body mass and, as such,
Holder, Roger L., Nevill, Alan M.
core   +3 more sources

Longitudinal association of adiposity with wheezing and atopy at 22 years: the 1993 Birth Cohort, Pelotas, Brazil

Journal of Asthma and Allergy, 2018
Ana Maria Baptista Menezes,1 Paula Duarte de Oliveira,1 Cauane Blumenberg,1 Efrain Sanchez-Angarita,2 Gloria Isabel Niño-Cruz,1 Ignacio Zabert,3 Janaina Calu Costa,1 Luiza Isnardi Cardoso Ricardo,1 Rafaela Costa Martins,1 Fernando César ...
Menezes AMB, Oliveira PD, Blumenberg C, Sanchez-Angarita E, Niño-Cruz GI, Zabert I, Costa JC, Ricardo LIC, Martins RC, Wehrmeister FC   +9 more
doaj  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source