Results 101 to 110 of about 1,171,043 (349)

Effect of Bimagrumab vs Placebo on Body Fat Mass Among Adults With Type 2 Diabetes and Obesity

JAMA Network Open, 2021
Key Points Question What are the effects of bimagrumab, an antibody that blocks activin type II receptors and stimulates skeletal muscle growth, on total body fat mass and glycemic control in patients with type 2 diabetes and excess adiposity?
S. Heymsfield, L. Coleman, Ram R Miller, D. Rooks, D. Laurent, O. Pétricoul, J. Praestgaard, Therese Swan, Thomas Wade, Robert G. Perry, B. Goodpaster, R. Roubenoff   +11 more
semanticscholar   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Population Pharmacokinetic Modeling To Estimate the Contributions of Genetic and Nongenetic Factors to Efavirenz Disposition [PDF]

, 2016
Efavirenz pharmacokinetics is characterized by large between-subject variability, which determines both therapeutic response and adverse effects.
Bies, Robert R., Desta, Zeruesenay, Lu, Jessica, Metzger, Ingrid F., Robarge, Jason D., Skaar, Todd C., Thong, Nancy   +6 more
core   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Physical fitness in preschool children in relation to later body composition at first grade in school.

PLoS ONE, 2021
BackgroundThis study aimed to investigate whether better physical fitness in kindergarten predicts later healthier body composition in first grade at school.MethodsBody composition was assessed by skinfold thickness measurements.
Kirkke Reisberg, Eva-Maria Riso, Jaak Jürimäe   +2 more
doaj   +1 more source

The relation between visceral adipose tissue accumulation and biochemical tests in university students. [PDF]

, 2005
We evaluated the visceral adipose tissue accumulation in university students in Okayama prefecture, Japan. Fifty-eight Japanese university students (10 men and 48 women, age 18.4 +/- 0.6 years)were enrolled in this study.
Fujii, Masafumi, Kira, Shohei, Kogashiwa, Michiko, Miyatake, Nobuyuki, Wang, Da-Hong, Yamasato, Teruhiro   +5 more
core   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Genetic markers of obesity risk: stronger associations with body composition in overweight compared to normal-weight children.

PLoS ONE, 2011
BackgroundGenetic factors are important determinants of overweight. We examined whether there are differential effect sizes depending on children's body composition.MethodsWe analysed data of n = 4,837 children recorded in the Avon Longitudinal Study of ...
Andreas Beyerlein, Rüdiger von Kries, Andrew R Ness, Ken K Ong   +3 more
doaj   +1 more source

Effect of a pedometer-based walking intervention on body composition in patients with ESRD: a randomized controlled trial. [PDF]

, 2020
BackgroundA randomized trial of a pedometer-based intervention with weekly activity goals led to a modest increase in step count among dialysis patients.
Johansen, Kirsten L, Kittiskulnam, Piyawan, Lai, Jennifer C, Sheshadri, Anoop   +3 more
core  

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source