Results 91 to 100 of about 982,573 (275)
Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases
BMEMat, EarlyView.This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou +6 more
wiley +1 more source
BMEMat, EarlyView.Multifunctional nano‐networks (NNWs) are prepared via reaction‐induced self‐assembly (RISA) of spermidine (SPD), epigallocatechin gallate (EGCG), 2‐formylphenylboronic acid (2‐FPBA), and deferoxamine (DFO) through dynamic iminoboronate bonds. These NNWs leverage the oxidative AKI microenvironment to trigger disintegration, enabling site‐specific ...
Juan Jin +17 more
wiley +1 more source
Novel skeletal effects of glucagon-like peptide-1 (GLP-1) receptor agonists [PDF]
, 2017 Type 2 diabetes mellitus (T2DM) leads to bone fragility and predisposes to increased risk of fracture, poor bone healing and other skeletal complications.
Chantal Chenu +4 more
core +5 more sources
Atomically precise metal cluster enzymes for pathological tissue regeneration
BMEMat, EarlyView.Schematic illustration of atomically precise metal cluster enzymes (MCEs) for pathological tissue regeneration. Atomically precise MCEs can modulate biological processes, such as attenuation of inflammatory responses, eradication of bacterial pathogens, regulation of angiogenesis, and promotion of cell development.
Ziqiang Xiong +11 more
wiley +1 more source
Aerobic Exercise and Pharmacological Treatments Counteract Cachexia by Modulating Autophagy in Colon Cancer [PDF]
, 2016 Recent studies have correlated physical activity with a better prognosis in cachectic patients, although the underlying mechanisms are not yet understood.
Adamo, S. +17 more
core +6 more sources
Exploration, EarlyView.This study introduces a bacterial biohybrid (Ec@ZFOY) designed to target deep tumor regions using a combination of magnetic and hypoxia‐driven mechanisms for enhanced therapeutic delivery. By incorporating hypoxia‐targeted Escherichia coli and magnetic nanoparticles loaded with a HIF‐1α inhibitor, the biohybrid activates ferroptosis through reactive ...
Sijie Shao +5 more
wiley +1 more source
The effects of graded levels of calorie restriction : V. Impact of short term calorie and protein restriction on physical activity in the C57BL/6 mouse [PDF]
, 2016 Peer reviewedPublisher ...
Chen, Luonan +11 more
core +3 more sources
Microengineering the Liver: Strategies for Constructing Functional Liver‐on‐a‐Chip Devices
Exploration, EarlyView.This review summarizes recent advances in liver‐on‐a‐chip (LOC) technologies, including fabrication strategies and functional integration approaches, and discusses their promising applications in drug screening and related biomedical fields. ABSTRACT Reliable in vitro liver models are indispensable for researching liver diseases and developing ...
Jie Wang +7 more
wiley +1 more source
Mechanisms of action and therapeutic applications of GLP-1 and dual GIP/GLP-1 receptor agonists
Frontiers in EndocrinologyGlucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are two incretins that bind to their respective receptors and activate the downstream signaling in various tissues and organs.
Qiyuan Keith Liu
doaj +1 more source
Pancreas Cancer-Associated Weight Loss. [PDF]
, 2019 Unintentional weight loss in patients with pancreatic cancer is highly prevalent and contributes to low therapeutic tolerance, reduced quality of life, and overall mortality.
Denlinger, Crystal S +7 more
core