Results 141 to 150 of about 982,573 (275)
The FASEB Journal, Volume 40, Issue 7, 15 April 2026.The helminth TGF‐β mimic TGM4 activates SMAD signaling in macrophages and T cells through canonical TGF‐β receptors and the CD44 co‐receptor, through Domains 1–5 (D1‐5). In fibroblasts, which express lower levels of CD44, TGM4 binds but does not transduce a signal; furthermore, it inhibits activation by agonist ligands such as TGF‐β itself, in a manner
Kyle T. Cunningham +15 more
wiley +1 more source
Advanced Science, Volume 13, Issue 19, 2 April 2026.This study identifies L‐type calcium channel blockers as novel ferroptosis inhibitors. It reveals that PKCβ, activated in calcium dependent manner, phosphorylates and activates ACSL4 and ALOX15, relocating them to lipid droplets to promote lethal lipid peroxidation and ferroptosis.
Guoyuan Hou +8 more
wiley +1 more source
Advanced Science, Volume 13, Issue 19, 2 April 2026.Staphylococcus aureus (S. aureus) infection creates a high‐lactate microenvironment, promoting p300‐mediated lactylation of PGK1 at lysine 361 (K361). Lactylated PGK1 translocates to the mitochondrial outer membrane and interacts with VDAC3. This interaction triggers FtMt downregulation, iron accumulation, and excessive PINK1/Parkin‐mediated mitophagy,
Han‐jun Qin +5 more
wiley +1 more source
Advanced NanoBiomed Research, Volume 6, Issue 4, April 2026.This review explains how biomaterials and nanoparticles can be used to induce or modulate tertiary lymphoid structures (TLSs), which are ectopic immune hubs that form in nonlymphoid tissues during chronic disease and cancer. By comparing different methods, the article highlights design principles for modeling TLSs or recapitulating specific TLS ...
Shaza Karaman, Mei ElGindi, Jeremy Teo
wiley +1 more source
Advanced NanoBiomed Research, Volume 6, Issue 4, April 2026.This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari +5 more
wiley +1 more source
Comprehensive Physiology, Volume 16, Issue 2, April 2026.Local complement production by pulmonary artery adventitial fibroblasts, activated intracellularly by CFD and CFB and extracellularly by GZMK+ CD8 T cells, and its secretion in soluble form and within EVs promotes macrophage and T cell chemotaxis and activation.
Hui Zhang +9 more
wiley +1 more source
Drug Testing and Analysis, Volume 18, Issue 4, Page 458-482, April 2026.New insights into drug metabolism, distribution, elimination, and detection assays for drugs and methods of sports doping published between 2024 and 2025 are critically reviewed and evaluated in context with the Prohibited List 2025 as established by the World Anti‐Doping Agency.
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley +1 more source
eFood, Volume 7, Issue 2, April 2026.MCL1 in promoting tamoxifen resistance by inhibiting apoptosis. This study demonstrates that the compound CPZ, identified through virtual screening and validated by molecular docking and experiments, directly binds to MCL1. This binding restores apoptosis and inhibits tumor growth, thereby combating resistance to endocrine therapy in breast cancer ...
Shujing Liu +9 more
wiley +1 more source
Molecular Carcinogenesis, Volume 65, Issue 4, Page 523-536, April 2026.ABSTRACT Canine hepatocellular carcinoma (HCC) requires further molecular characterization to identify diagnostic and therapeutic targets, and to establish whether dogs with this condition can model the human disease. Accordingly, we aimed to identify differentially expressed genes (DEGs) in canine HCC and evaluate cross‐species transcriptomic ...
Mohammad Arif +8 more
wiley +1 more source