Results 151 to 160 of about 982,573 (275)

Targeting Multiple Gut‐Brain Pathways in Obesity: Rationale for Combination Pharmacotherapy

Obesity Science &Practice, Volume 12, Issue 2, April 2026.
ABSTRACT Background As a disease of energy dysregulation, obesity involves metabolic, hormonal, and neural factors, the interconnection of which is referred to as the “gut‐brain axis.” Objective This review aimed to provide an overview of the clinical evidence of physiological and objective or subjective changes in eating behavior with gut hormone ...
Alexander D. Miras, Muzamil Hussain
wiley   +1 more source

ApoJ regulates endothelial lipase activity and stability

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Endothelial lipase (EL) is a key regulator of high‐density lipoprotein (HDL) metabolism. Many aspects of EL function remain incompletely understood due to challenges in purifying active EL. This study identifies apolipoprotein J (ApoJ) as a novel chaperone for EL, crucial for its solubility and activity.
Uriel L. Jean‐Baptiste, Simcha R. Singh, Ming J. Wu, Kellen Christina da Cruz Rodriguez, Young‐Bum Kim, Saskia B. Neher   +5 more
wiley   +1 more source

Hitchhiker's Guide to the Swampland: The Cosmologist's Handbook to the String‐Theoretical Swampland Programme

Fortschritte der Physik, Volume 74, Issue 4, April 2026.
Abstract String theory has strong implications for cosmology, implying the absence of a cosmological constant, ruling out single‐field slow‐roll inflation, and that black holes decay. The origins of these statements are elucidated within the string‐theoretical swampland programme.
Kay Lehnert
wiley   +1 more source

Incretin Mimetics in Cancer and Cardiovascular Disease: JACC: CardioOncology State-of-the-Art Review. [PDF]

JACC CardioOncol
Leong D, Gong S, Sattar N, Narayan V, Reizine NM, Gerstein H, Vellky J.   +6 more
europepmc   +1 more source

Patient‐Reported Outcomes After Treatment With OnabotulinumtoxinA for Platysma Prominence: Results From a Phase 2 Dose‐Ranging Study

Journal of Cosmetic Dermatology, Volume 25, Issue 4, April 2026.
ABSTRACT Background Repetitive contractions of the platysma muscle may result in vertical neck bands that blunt the jawline (i.e., platysma prominence [PP]). We report patient‐reported outcomes (PROs) from a phase 2 study evaluating onabotulinumtoxinA (onabotA) for moderate or severe PP.
Shannon Humphrey, Sandhya Shimoga, Joely Kaufman, David Bank, Brian Biesman, Christy Harutunian, Grace S. West, Warren Tong, Vaishali Patel   +8 more
wiley   +1 more source

LJ-1888, a selective antagonist for the A3 adenosine receptor, ameliorates the development of atherosclerosis and hypercholesterolemia in apolipoprotein E knock-out mice [PDF]

, 2018
Jeong, Lak Shin, Jeong, Se-Jin, Kim, Gyudong, Oh, Goo Taeg, Park, Jong-Gil, Yu, Jinha   +5 more
core   +1 more source

Targeting the LPI/GPR55 Axis in MAFLD and MASH: Novel Insights, Therapeutic Strategies and Future Directions

Liver International, Volume 46, Issue 4, April 2026.
ABSTRACT Metabolic dysfunction‐associated fatty liver disease (MAFLD), recently redefined from non‐alcoholic fatty liver disease (NAFLD), highlights the central role of metabolic dysfunction in its pathophysiology. The L‐α‐lysophosphatidylinositol/G protein‐coupled receptor 55 (LPI/GPR55) axis, an element of the endocannabinoidome, has emerged as a key
Jerome Lian, Ricky R Lareu, Mohan Patil, Marco Falasca   +3 more
wiley   +1 more source

Dietary and Pharmacological Modulation of Aging-Related Metabolic Pathways: Molecular Insights, Clinical Evidence, and a Translational Model. [PDF]

Int J Mol Sci
Murillo-Cancho AF, Lozano-Paniagua D, Nievas-Soriano BJ.   +2 more
europepmc   +1 more source

Low‐dose lithium supplementation promotes musculoskeletal and metabolic health in ovariectomized female mice

The Journal of Physiology, Volume 604, Issue 7, Page 2845-2866, 1 April 2026.
Abstract figure legend Low‐dose lithium supplementation in ovariectomized mice enhances skeletal muscle contractility (isometric force and fatigue resistance), SERCA function and promotes favourable transcriptional reprogramming, while increasing bone density and modestly improving insulin sensitivity.
Bianca M. Marcella, Jessica L. Braun, Amélie A.T. Marais, Briana L. Hockey, Mia S. Geromella, Ryan W. Baranowski, Rene Vandenboom, Rebecca E.K. MacPherson, Val A. Fajardo   +8 more
wiley   +1 more source

Investigation of exercise-mimetic bioactive molecules as modulators of MMP activity and expression in cancer cells. [PDF]

J Enzyme Inhib Med Chem
Vo HVT, Patton GN, Park JS, Kim SJ, Kim N, Lee HJ.   +5 more
europepmc   +1 more source