Results 31 to 40 of about 982,573 (275)

Oral Apolipoprotein A-I Mimetic D-4F Lowers HDL-Inflammatory Index in High-Risk Patients: A First-in-Human Multiple-Dose, Randomized Controlled Trial. [PDF]

, 2017
A single dose of the apolipoprotein (apo)A-I mimetic peptide D-4F rendered high-density lipoprotein (HDL) less inflammatory, motivating the first multiple-dose study. We aimed to assess safety/tolerability, pharmacokinetics, and pharmacodynamics of daily,
Bloedon, LeAnne T., Duffy, Danielle, Dunbar, Richard L., Fogelman, Alan M., Movva, Rajesh, Navab, Mohamad, Norris, Robert B., Rader, Daniel J.   +7 more
core   +2 more sources

Co-targeting of Bcl-2 and mTOR pathway triggers synergistic apoptosis in BH3 mimetics resistant acute lymphoblastic leukemia [PDF]

, 2015
Several chemo-resistance mechanisms including the Bcl-2 protein family overexpression and constitutive activation of the PI3K/Akt/mTOR signaling have been documented in acute lymphoblastic leukemia (ALL), encouraging targeted approaches to circumvent ...
ALLEGRETTI, MATTEO, Bergamo, P, FOA, Roberto, Iacovelli, S, LICCHETTA, ROBERTO, Martelli, Am, Mccubrey, Ja, Milella, M, MIRABILII, SIMONE, RICCIARDI, Maria Rosaria, Rinaldo, C, TAFURI, Agostino, Zeuner, A   +12 more
core   +1 more source

Quality, Thermo-Rheology, and Microstructure Characteristics of Cubic Fat Substituted Pork Patties with Composite Emulsion Gel Composed of Konjac Glucomannan and Soy Protein Isolate

Gels
Composite emulsion gel can effectively mimic animal adipose tissue. In this study, composite emulsion gels composed of soy protein isolates and konjac glucomannan (KGM) were prepared as plant-based cubic fat substitutes (CFS).
Lai Wei, Yuqing Ren, Lu Huang, Xinnan Ye, He Li, Jian Li, Jinnuo Cao, Xinqi Liu   +7 more
doaj   +1 more source

Effects of Flaxseed (Linum Usitatissimum) As Fat Mimetics on Physicochemical and Sensory Properties of Muffin

Journal of Academia, 2021
Muffin is a sweet baked product with soft texture and good taste. Egg as one of the main ingredients in muffins plays a pivotal role in maintaining nutritional and physical properties of baked products. However, eggs have high cholesterol content and are
Nurul Ashikin Mohammad Zaki , Noorlaila Ahmad , Nurul Nor Izzuani Nor Sham   +2 more
doaj  

The GLP-1 Receptor Agonist Exenatide Ameliorates Bone Composition and Tissue Material Properties in High Fat Fed Diabetic Mice

Frontiers in Endocrinology, 2019
Type 2 diabetes mellitus (T2DM) has recently been recognized as a significant risk factor for bone fragility. Careful investigations of bone mechanical properties in human studies suggested possible alterations of bone composition, although this axis has
Sity Aishah Mansur, Aleksandra Mieczkowska, Peter R. Flatt, Daniel Chappard, Daniel Chappard, Daniel Chappard, Nigel Irwin, Guillaume Mabilleau, Guillaume Mabilleau, Guillaume Mabilleau   +9 more
doaj   +1 more source

Reversal of obesity and insulin resistance by a non-peptidic glucagon-like peptide-1 receptor agonist in diet-induced obese mice. [PDF]

PLoS ONE, 2010
BACKGROUND: Glucagon-like peptide-1 (GLP-1) is recognized as an important regulator of glucose homeostasis. Efforts to utilize GLP-1 mimetics in the treatment of diabetes have yielded clinical benefits.
Min He, Haoran Su, Weiwei Gao, Stina M Johansson, Qing Liu, Xiaoyan Wu, Jiayu Liao, Andrew A Young, Tamas Bartfai, Ming-Wei Wang   +9 more
doaj   +1 more source

Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2 [PDF]

, 2014
The antiglycemic drug metformin, widely prescribed as first-line treatment of type II diabetes mellitus, has lifespan-extending properties. Precisely how this is achieved remains unclear.
Billen, Johan, Braeckman, Bart, De Haes, Wouter, Depuydt, Geert, Frooninckx, Lotte, Schoofs, Liliane, Smolders, Arne, Temmerman, Liesbet, Van Assche, Roel   +8 more
core   +1 more source

Reduction of SPARC protects mice against NLRP3 inflammasome activation and obesity

The Journal of Clinical Investigation, 2023
The comprehensive assessment of long-term effects of reducing intake of energy (CALERIE-II; NCT00427193) clinical trial established that caloric restriction (CR) in humans lowers inflammation. The identity and mechanism of endogenous CR-mimetics that can
Seungjin Ryu, Olga Spadaro, Sviatoslav Sidorov, Aileen H. Lee, Sonia Caprio, Christopher Morrison, Steven R. Smith, Eric Ravussin, Irina Shchukina, Maxim N. Artyomov, Yun-Hee Youm, Vishwa Deep Dixit   +11 more
doaj   +1 more source

HDL and CER-001 Inverse-Dose Dependent Inhibition of Atherosclerotic Plaque Formation in apoE-/- Mice: Evidence of ABCA1 Down-Regulation. [PDF]

PLoS ONE, 2015
CER-001 is a novel engineered HDL-mimetic comprised of recombinant human apoA-I and charged phospholipids that was designed to mimic the beneficial properties of nascent pre-ß HDL.
Claudine Tardy, Marine Goffinet, Nadia Boubekeur, Guy Cholez, Rose Ackermann, Gavin Sy, Constance Keyserling, Narendra Lalwani, John F Paolini, Jean-Louis Dasseux, Ronald Barbaras, Rudi Baron   +11 more
doaj   +1 more source

Effects of canola and corn oil mimetic on Jurkat cells [PDF]

, 2011
BACKGROUND: The Western diet is high in omega-6 fatty acids and low in omega-3 fatty acids. Canola oil contains a healthier omega 3 to omega 6 ratio than corn oil.
Gabriela Ion, Kayla Fazio, Juliana A Akinsete, W Elaine Hardman   +3 more
core   +2 more sources