Results 71 to 80 of about 982,573 (275)

Structure-based discovery of hydrocarbon-stapled paxillin peptides that block FAK scaffolding in cancer

Nature Communications
The focal adhesion kinase (FAK) scaffold provides FAK-targeted cancer therapeutics with greater efficacy and specificity than traditional kinase inhibitors. The FAK scaffold function largely involves the interaction between FAK’s focal adhesion targeting
Lauren Reyes, Lena Naser, Warren S. Weiner, Darren Thifault, Erik Stahl, Liam McCreary, Rohini Nott, Colton Quick, Alex Buchberger, Carlos Alvarado, Andrew Rivera, Joseph A. Miller, Ruchi Khatiwala, Brian R. Cherry, Ronald Nelson, Jose M. Martin-Garcia, Nicholas Stephanopoulos, Raimund Fromme, Petra Fromme, William Cance, Timothy Marlowe   +20 more
doaj   +1 more source

A cyclic peptide-grafted Fc with hepatocyte growth factor functionality ameliorates hepatic fibrosis in a non-alcoholic steatohepatitis mouse model

iScience
Summary: The regenerative functions associated with cytokines and growth factors have immense therapeutic potential; however, their poor pharmacokinetics, resulting from structural features, hinder their effectiveness.
Nichole Marcela Rojas-Chaverra, Ryu Imamura, Hiroki Sato, Toby Passioura, Emiko Mihara, Tatsunori Nishimura, Junichi Takagi, Hiroaki Suga, Kunio Matsumoto, Katsuya Sakai   +9 more
doaj   +1 more source

Novel GLP-1 Analog Supaglutide Stimulates Insulin Secretion in Mouse and Human Islet Beta-Cells and Improves Glucose Homeostasis in Diabetic Mice

Frontiers in Physiology, 2019
Glucagon-like peptide-1 (GLP-1), an incretin hormone plays an important role in regulating glucose homeostasis. The therapeutic use of native GLP-1 is inadequate due to its short in vivo half-life. We recently developed a novel GLP-1 mimetics supaglutide,
Liwei Ren, Qiaoli Cui, Wenjuan Liu, Liqian Wang, Yijing Liao, Ying Feng, Wanwan Sun, Yehong Yang, Zhaoyun Zhang, Tianru Jin, Tianru Jin, Gerald J. Prud’homme, Lina Zhang, Yiming Li, Ying Leng, Qinghua Wang   +15 more
doaj   +1 more source

Aligned Fibronectin Microenvironment Temporally Facilitates Profibrotic Fibroblast Activation via Integrin α5β1

Advanced Science, EarlyView.
Compared to a healthy random nanofibrous fibronectin microenvironment, a fibrotic aligned nanofibrous fibronectin microenvironment employs a specific integrin, α5β1 integrin, to activate early pro‐fibrotic fibroblast behaviors and later fibrotic fibroblast tissue formation with cell/F‐actin alignment, α‐SMA expression, and cell‐driven aligned ...
Doğuhan Beyatlı, Mika Brown, George‐Radu Romanescu, Seungkuk Ahn   +3 more
wiley   +1 more source

Five Neuropeptide Ligands Meet One Receptor: How Does This Tally? A Structure-Activity Relationship Study Using Adipokinetic Bioassays With the Sphingid Moth, Hippotion eson

Frontiers in Endocrinology, 2019
Adipokinetic hormones (AKHs) play a major role in mobilizing stored energy metabolites during energetic demand in insects. We showed previously (i) the sphingid moth Hippotion eson synthesizes the highest number of AKHs ever recorded, viz.
Heather G. Marco, Gerd Gäde
doaj   +1 more source

Post‐Translational Regulation of CD8+ T Cell Fate and Dysfunction in Tumor Immunity

Advanced Science, EarlyView.
This review delineates how post‐translational modifications (PTMs) function as a central regulatory interface governing CD8+ T cell activation, differentiation, persistence, and exhaustion in antitumor immunity. By integrating antigenic, metabolic, and microenvironmental cues, diverse PTM programs coordinate transcriptional and chromatin states that ...
Zihao Zhou, Xu Chen, Nina Li, Meiyan Zou, Yunfan Lin, Pei Lin, Weiyao Feng, Xinyuan Zhao, Li Cui   +8 more
wiley   +1 more source

Physicochemical properties of low-fat soft cheese Turkish Beyaz made with bacterial cellulose as fat mimetic

International Journal of Dairy Technology, 2011
The effects of incorporating various concentrations of bacterial cellulose (BC) (1.7 and 3.5% w/v) on the physicochemical and sensorial properties of low-fat soft cheese Turkish Beyaz were investigated during a 60-day ripening period. Control cheeses were produced using nonfat, half-fat (1.7% fat) and full-fat milk, for comparison.
Akoglu, Aylin, CAKMAKC, M. Lutfu, KART, Arzu, Karahan, Aynur Gül   +3 more
openaire   +3 more sources

Vascularized Cardiac Tissue Engineering: From Advances in Biofabrication to Translational Applications

Advanced Science, EarlyView.
This review presents a process‐oriented framework for vascularized cardiac tissue engineering, highlighting how the coordinated design of cells, biomaterials, and biofabrication strategies enables the functional development or vascularized myocardium for disease modelling and drug discovery.
Yang Liu, Zijie Zhang, Hongbin Li, Lino Prados‐Martin, Huanhong Li, Feng Cheng, Xia Tu, Khoon S. Lim, Wanlu Li, Mian Wang   +9 more
wiley   +1 more source

Evaluation of the current knowledge limitations in breast cancer research: a gap analysis [PDF]

, 2008
BACKGROUND A gap analysis was conducted to determine which areas of breast cancer research, if targeted by researchers and funding bodies, could produce the greatest impact on patients.
A Cox, A Howell, A Kamb, A Maurice, A Moyer, A Renwick, A Rodger, Adrian Harris, AH Eliassen, AH Sims, Alastair Thompson, Angela Cox, Anthony Howell, C Julian-Reynier, C Kuperwasser, CA Purdie, CD Wagner, CH Kroenke, Charles Streuli, CJ Watson, CJ Watson, CM Perou, D Sachdev, DF Easton, Diana Harcourt, DJ Britton, DJ Hunter, DM Abd El-Rehim, DM Harcourt, DS Main, E Amir, E Katz, E Tiligada, G Bon, GP Gui, GW Sledge, H Goulding, HE Huang, Ingunn Holen, International Agency for Research on Cancer Expert Group, IO Ellis, J Bogaerts, J Brennan, J Brett, J Corner, J Debnath, J Polanowska, J Stingl, J Teulière, JJ Dignam, JK Camoriano, JL Jones, JM Bartlett, JM Dixon, JM Gee, JT Scott, Julia Gee, JW Jonker, K Polyak, K Rennstam, KA Green, KE Sleeman, Keith Brennan, KJ Fowler, KL Schwertfeger, KR Brennan, KW Kinzler, L Cortesi, L Fallowfield, L Hennighausen, L Larue, L Lostumbo, LL Northouse, LS Freedman, M Adams, M Harvie, M Harvie, M Shackleton, M Sidani, M Tanner, M Zhang, MD Holmes, MD Sternlicht, MD Sternlicht, Michael Steel, Michelle Harvie, MJ Piccart-Gebhart, ML Asselin-Labat, ML McNeely, ML McNeely, MM Ip, MO Leach, N Barnes, N Rahman, N Sarwar, NG Howlett, P Dent, P Schofield, PA Kenny, R DasGupta, R Doll, R Leake, R Scully, R Serra, RA Walker, RB Clarke, Robert Nicholson, RT Chlebowski, S Anand, S Hiscox, S Seal, S Stylianou, SA Bingham, SE Moody, SJ Cleator, SK Sharan, SN Stacey, SR Johnston, T Sheard, T Sjöblom, T Sorlie, The Breast Cancer Association Consortium, The CHEK2 Breast Cancer Case-Control Consortium, V Aranda, V Speirs, VA McCormack, VG Vogel, WD Foulkes, X Yu, YL Low   +129 more
core   +5 more sources

Effect of fat mimetics on physical, textural and sensory properties of cookies [PDF]

International Journal of Food Properties, 2000
Abstract Soft‐type cookies were prepared with up to 35% fat replacement by fat mimetics, namely Litesse (improved polydextrose), C*deLight MD 01970 (maltodextrins), Dairytrim (b‐glucans), pectin and Simplesse Dry 100 (a blend of micropatriculated whey proteins and emulsifiers). Physical, textural and sensory properties of the cookies were measured. All
E. I. Zoulias, V. Oreopoulou, C. Tzia
openaire   +1 more source