Results 51 to 60 of about 344,028 (306)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Macronutrients as sources of food energy. [PDF]

, 2005
This background paper considers the extent to which the development of new recommendations for dietary energy requirements needs to account for the macronutrient (fat, carbohydrate, protein and alcohol) profiles of different diets.
Prentice, Andrew M
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Postprandial de novo lipogenesis and metabolic changes induced by a high-carbohydrate, low-fat meal in lean and overweight men [PDF]

, 2001
BACKGROUND: Adjustments of carbohydrate intake and oxidation occur in both normal-weight and overweight individuals. Nevertheless, the contribution of carbohydrates to the accumulation of fat through either reduction of fat oxidation or stimulation of
Ansorena-Artieda, D. (Diana), Astiasarán, I. (Iciar), Forga, L. (Luis), Marques-Lopes, I. (Iva), Martinez, J.A. (José Alfredo)   +4 more
core  

The removal of thermally aged films of triacylglycerides by surfactant solutions [PDF]

, 2013
Thermal ageing of triacylglycerides (TAG) at high temperatures produces films which resist removal using aqueous surfactant solutions. We used a mass loss method to investigate the removal of thermally aged TAG films from hard surfaces using aqueous ...
B-H Chen, B-H Chen, CA Miller, CP Tan, CP Tan, E Choe, EJ Alameda, EJ Alameda, EJ Alameda, EP Kalogianni, JP Guthrie, K Gotoh, KH Raney, M Tsubouchi, OC Johnson, P Mukherjee, Paul D. I. Fletcher, PS Hess, T Hilditch, Timothy S. Dunstan, VW Reid, WJ Muizbelt, WR Lewis   +22 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Metabolic impact of protein feeding prior to moderate-intensity treadmill exercise in a fasted state: a pilot study

Journal of the International Society of Sports Nutrition, 2018
Background Augmenting fat oxidation is a primary goal of fitness enthusiasts and individuals desiring to improve their body composition. Performing aerobic exercise while fasted continues to be a popular strategy to achieve this outcome, yet little ...
Bradley T. Gieske, Richard A. Stecker, Charles R. Smith, Kyle E. Witherbee, Patrick S. Harty, Robert Wildman, Chad M. Kerksick   +6 more
doaj   +1 more source

Effects of sprint interval training on substrate oxidation in adults living with and without obesity: The i‐FLEX study

Physiological Reports, 2021
Metabolic flexibility is the ability to adapt substrate oxidation according to metabolic demand. Exercise increases fat oxidation responses in individuals living with obesity; however, limited research exists on the relationship between substrate ...
Benjamin H. Colpitts, Ken Seaman, Ashley L. Eadie, Keith R. Brunt, Danielle R. Bouchard, Martin Sénéchal   +5 more
doaj   +1 more source

Low carbohydrate high fat ketogenic diets on the exercise crossover point and glucose homeostasis

Frontiers in Physiology, 2023
In exercise science, the crossover effect denotes that fat oxidation is the primary fuel at rest and during low-intensity exercise with a shift towards an increased reliance on carbohydrate oxidation at moderate to high exercise intensities.
T. D. Noakes, P. J. Prins, J. S. Volek, D. P. D’Agostino, D. P. D’Agostino, A. P. Koutnik   +5 more
doaj   +1 more source