Results 201 to 210 of about 390,800 (268)

SSR4 sustains Tertiary Lymphoid Structures by Regulation Quality Control of N‐linked Glycosylation During B‐cell Differentiation Into Plasmacyte in Colorectal Cancer

Advanced Science, EarlyView.
SSR4, a TRAP component induced in B cells, governs BAFFR N‐glycosylation via DDOST to sustain NF‐κB signaling, B‐cell differentiation, and TLS maturation. Its loss impairs anti‐tumor immunity, while overexpression improves antibody glycosylation and ADCC, revealing a critical regulator for cancer immunotherapy.
Wei Zhao, Youcai Zhao, Haiyang Li, Bowen Yang, Siyan Lu, Xueting Fu, Caixia Zhang, Yirong Chen, Xiaofeng Bian, Xinghua Ma, Xiaobing Yang, Bin Wang, Yuan Fang, Lulu Yang, Yelin Zhao, Shuli Zhao   +15 more
wiley   +1 more source

The T Cell Receptor: Molecular Sensor, Therapeutic Mediator and Probabilistic Driver of Adaptive Immunity. [PDF]

Immunol Rev
Schober K.
europepmc   +1 more source

The fate of sporozoites.

Bulletin of the World Health Organization, 2000
openaire   +2 more sources

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

Stromal Prostaglandin is a Dominant Spatial Regulator of Cell-fate Plasticity in Colorectal Cancer

Tape C, Molyneux C, O'Sullivan R, Mulholland-Illingworth E, Moore J, Li N, Vlckova P, Amirkhah R, Dobric A, Crampsie S, Wilkinson A, Langley J, Alonso ML, Campbell A, Claus J, Krishnaswamy S, Dunne P, Leedham S.   +17 more
europepmc   +1 more source

Developmental organization of sensory and sympathetic ganglia. [PDF]

Nature
Vong KI, Alvarez YD, Zhang Q, Weng J, Noel G, Barton ST, Chung C, Howarth R, Meave N, Jiwani F, Patarlapalli SB, Yao F, Zhu F, Barrows C, Patel A, Wang JX, Chi NC, Kingsmore SF, White MD, Yang X, Gleeson JG.   +20 more
europepmc   +1 more source

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source

Neural stem cell epigenomes and fate bias are temporally coordinated during mouse cortical development. [PDF]

Genes Dev
Shapira Y, Noack F, Vangelisti S, Chong F, Lifshitz A, Tanay A, Bonev B.   +6 more
europepmc   +1 more source

MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes

Advanced Science, EarlyView.
A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak, Juliane Tschuck, Stefanie A. I. Weiß, Daniel Kaemena, Karolin Klimm, Ana Galhoz, Larissa Ringelstetter, Myles Fennell, Juliane Merl‐Pham, Anna Artati, Stefanie Strasser, Ralph Garippa, Michael Witting, Hans Zischka, Joel A. Schick, Stefanie M. Hauck, Michael P. Menden, Michelle Vincendeau, Brent R. Stockwell, Kamyar Hadian   +19 more
wiley   +1 more source

Induced Pluripotent Stem Cells as a Tool to Decipher the Normal and Abnormal Development of the Esophagus and Trachea from Normal Morphogenesis to Esophageal Atresia, Tracheomalacia, and Laryngo-Tracheal Clefts. [PDF]

Cells
Zhang Y, David A, Nemati A, Faure C.
europepmc   +1 more source