Results 31 to 40 of about 439,844 (312)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) masquerading as CNS demyelination

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2022
Background CADASIL is the most common single-gene disorder causing ischemic stroke. CADASIL has been linked to mutations in NOTCH3 gene, due to heterozygous missense mutations.
Sudhan Rackimuthu, Safwan Ahmed, Pawan Raj Pulu Ishwara, Anto J. Richie, K. Vimala Christina Colaco   +4 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Parents’ willingness to vaccinate their child against COVID 19: A cross sectional study [PDF]

Al Ameen Journal of Medical Sciences
Background: An effective COVID vaccine in children will decrease the severity of illness in children as well as transmission rates of the virus, thereby providing direct and indirect benefits.
Sowmya SG, Shreya Adavalath, K. Shreedhara Avabratha   +2 more
doaj  

Patients’ Attitudes Toward Care by Male Nurses in a Tertiary Care Center in Mangalore

Social Medicine
Background. Nursing is a profession that combines technical expertise with empathy to alleviate suffering and promote well-being. Although the number of male nurses has been increasing, the field is still widely regarded as female-dominated, a ...
Jooli Mathew, Selinamma Devasia Dhanya, Simy P.U., Mamatha M., Mamadevi, Alna Augustine   +5 more
doaj   +1 more source

Correction: Bronchiectatic Actinomycosis with Osseous Metaplasia Masquerading as Lung Cancer [PDF]

Türk Patoloji Dergisi
After the publication of the original article, the authors noticed an error in the departmental affiliation of one of the contributors, Don MASCARENHAS. The corrected version of the department is provided below, and the original article has been updated ...
Archana BHAT, Manjunath J, Don MASCARENHAS   +2 more
doaj   +1 more source

Separated fathers and the ‘fathers’ rights’ movement [PDF]

Journal of Family Studies, 2012
AbstractSeparated fathers often feel profound grief, distress, and anger at the end of their relationships with their partners and their children. Some participate in fathers’ rights’ groups, a movement which claims to advocate on behalf of men and fathers who are the victims of discrimination and injustice in the Family Court and elsewhere.
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

“Saving the crippled foot” – a study on diabetic foot ulcers and its salvage using flap surgeries

Journal of the Foot & Ankle
Objective: Emphasize the importance of a comprehensive and aggressive management with surgical debridement and flap-based reconstruction of defects in patients with diabetic foot ulcers (Ganga Class 3), and in turn, focusing on limb salvage.
Akhil Xavier Joseph, Latheesh Leo, Mohieb Mustak Ahamed, Tanya Mohanraj, Vivian D'Almeida   +4 more
doaj   +1 more source

Delusional disorder of snake infestation – A diagnostic dilemma

Kerala Journal of Psychiatry, 2019
Delusional infestation is a condition where one believes that he or she has a large parasitic infestation. We present a case with delusion of snake infestation as the only psychotic symptom without any primary psychotic or mood disorder.
K Priya Nayak, Safeekh A T
doaj   +1 more source