Results 81 to 90 of about 439,844 (312)

Detection of Protein–Protein Interactions in Escherichia coli With Single Molecule Sensitivity

Advanced Science, EarlyView.
This article describes a regulatory circuit in Escherichia coli able to detect protein–protein interactions with exquisite sensitivity. The interaction between two hybrid proteins fused to Bordetella pertussis adenylate cyclase and its activator calmodulin triggers a potent cyclic AMP signaling cascade.
Marilyne Davi, Daniel Ladant
wiley   +1 more source

Exploring the father-son relationship in college men

, 2012
On campuses and institutions across the country college men have emerged as a new at-risk group due to concerns of academic, social, emotional, health related, conduct related, and attitudinal natures. This study utilized phenomenological interviewing to
Lam, Andrew H.
core  

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source

My God and Father, while I stray

, 1884
My God, my Father while I strayG MajorWords written by C.

core  

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Optimizing CT pulmonary angiography: comparison of radiation dose, contrast volume, and image quality between standard and low-dose protocols

The Egyptian Journal of Radiology and Nuclear Medicine
Background Pulmonary embolism (PE) is a potentially life-threatening condition that requires prompt and accurate diagnosis. Computed tomography pulmonary angiography (CTPA) is the reference standard for PE detection; however, it carries risks of ...
Prema H, Mahesh M, Sampritha U, Kevin Aranha   +3 more
doaj   +1 more source

Father Joseph McNulty interview, 12 October 2003

, 2003
The oral history interview with Father Joseph McNulty, conducted on October 12, 2003, captures his reflections on the events of September 11, 2001, and their impact on both his personal experiences and the community of Tremont, Cleveland.

core  

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

Advanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu, Bingwei Wang, Zhijie Su, Xiaoxv Han, Miao He, Yun Zhao, Yujia Hou, Daotong Li, Weiguang Zhang, Lihua Qin, Ke Wang, Yanchun Li, Yi Yan, Siwang Yu, Xiaoshuai Huang, Tairan Yuwen, Jianyuan Luo, Ruimao Zheng   +17 more
wiley   +1 more source

Analyzing the Environmental Risk Factors of Leptospirosis in Hospitalized Patients, a Case Control Study

Online Journal of Health & Allied Sciences
Background: Leptospirosis is a zoonotic disease, particularly prevalent in tropical and subtropical regions. It often presents as pyrexia of unknown origin (PUO), with transmission linked to environmental exposures such as contact with contaminated water
Samuel Philip Dsouza, Kavitha Prabhu, Supriya Vinisha Crasta, Anushka Pramod Ullal, Amaan Hishaam, Ian John Antony Colaco, Shruthi Vasanthaiah   +6 more
doaj  

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source