Results 111 to 120 of about 615,774 (275)

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts

Advanced Science, EarlyView.
We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang, Yuli Zhang, Zixin Kang, Jiayun Xiong, Ronghua Yang, Kang Ning   +5 more
wiley   +1 more source

An Exploratory Analysis of Father Involvement in Low-Income Families [PDF]

Using data from the Fragile Families study, this paper explores factors that influence paternal involvement in low-income families. 4873 fathers from the Fragile Families study were classified using CART (Classification and Regression Tree Analysis ...
Eric Turkheimer, Gina R. Hijjawi, Melvin N. Wilson   +2 more
core  

Black Single Custodial Fathers: Factors Influencing the Decision to Parent [PDF]

, 2003
This pilot study combined narrative and quantitative data to explore the factors enabling and motivating single African American fathers to take full custody of one or more of their children.
Coles, Roberta
core   +1 more source

Metabolic Reprogramming Driven by Trophoblasts and Decidual XCR1+PMN‐MDSC Crosstalk Controls Adverse Outcomes Associated With Advanced Maternal Age

Advanced Science, EarlyView.
The interaction between trophoblasts and decidual polymorphonuclear myeloid‐derived suppressor cells (dPMN‐MDSCs) via the XCL1–XCR1 axis is crucial for fetal development during the third trimester. Disruption of this axis impairs FOXO1 activity and causes metabolic imbalance in dPMN‐MDSCs, contributing to adverse outcomes associated with advanced ...
Meiqi Chen, Yuxiong Guo, Qing Zhao, Jingping Liu, Shuyi Kuang, Zhengcong Huang, Chenlin Lv, Shuxiu Xu, Zekai Zhuang, Anyan Yang, Jing Li, Kai Wu, Yumei He   +12 more
wiley   +1 more source

Natal Family Disruptions and Lives in Non-Parental Care:Impacts on Children’s Emotional Health and Academic Success [PDF]

, 2020
This research used a mixed methods design to evaluate the negative impacts of strains in children’s natal family environment, on their emotional and academic core self-concept, as well as how healthy non-parental relationships can help repair the damaged
Heid, Juliet
core   +1 more source

Modulating Integrin and Growth Factor Signaling With Peptides: Strategies to Synergistically Enhance Bone Tissue Regeneration

Advanced Science, EarlyView.
It has been demonstrated that, in the bone extracellular matrix (ECM), integrins and growth factor receptors (GFRs) engage in synergistic signaling to guide bone healing and regeneration. This review provides a comprehensive overview of current strategies using ECM‐derived peptides to recreate the cellular microenvironment and harness synergistic ...
Lluís Oliver‐Cervelló, Elisabetta Ada Cavalcanti‐Adam, Carlos Mas‐Moruno   +2 more
wiley   +1 more source

Dutch midwives’ views on father-involvement practices

Midwifery
Midwives are uniquely positioned to engage fathers already prenatally and facilitate an equal transition into parenthood for both parents. However, they may face barriers hindering their investment in involving fathers.The aim was to investigate barriers and facilitators midwives experience when implementing two father-involvement practices 1 ...
Lianne Aarntzen, Anna Seijmonsbergen-Schermers, Rutger Blom, Jens Henrichs, Belle Derks   +4 more
openaire   +5 more sources

Single-Father Families: A Review of the Literature [PDF]

, 2015
The number of children residing in single-father families in the United States quadrupled as a proportion of children\u27s living arrangements during the past few decades of the 20th century.
Coles, Roberta L.
core   +1 more source

NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement

Advanced Science, EarlyView.
This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang, Zemin Jiang, Qiaoyun Yang, Hong Zheng, Minghao Wang, Chennianci Zhu, Lih‐Wen Deng, Karen Carmelina Crasta, Yih‐Cherng Liou   +8 more
wiley   +1 more source