Results 41 to 50 of about 748,269 (346)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Mentoring fathers who grapple with fatherhood issues in a faith-based context: A pastoral-theological review

open access: yesIn die Skriflig, 2021
Fathers find themselves increasingly in a social crisis, the fatherhood dilemma, and are misrepresented in various studies and theories intended to shed light on the relationship between mothers and children.
Fazel E. Freeks
doaj   +1 more source

Challenging Behaviors in Young Children: The Father\u27s Role [PDF]

open access: yes, 2004
In this study, the authors examined the parenting practices, developmental expectations, and stress levels of 136 fathers and the challenging and prosocial behaviors of their 1- to 5-year-old children.
Burbach, Ann D   +2 more
core   +1 more source

A prospective longitudinal study of perceived infant outcomes at 18-24 months: Neural and psychological correlates of parental thoughts and actions assessed during the first month postpartum [PDF]

open access: yes, 2015
The first postpartum months constitute a critical period for parents to establish an emotional bond with their infants. Neural responses to infant-related stimuli have been associated with parental sensitivity.
Cole, Pamela M.   +6 more
core   +2 more sources

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

open access: yesFEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

“Opening up a well of emotions”: A qualitative study of men's emotional experiences in the transition to fatherhood

open access: yesNursing Open, 2023
Aim To explore the emotional changes and reactions men experience in their transition to fatherhood. Design This study used a qualitative design. Methods Data were collected through in‐depth interviews with 13 Norwegian fathers.
Beate Solberg   +3 more
doaj   +1 more source

Just as they expected: How parents' expectations about their unborn child's characteristics provide a context for early transactions between parenting and child temperament

open access: yesFrontiers in Psychology, 2022
Prenatal expectations about what children will be like after birth may provide a context for how parents perceive their infant's actual temperament. We examined how these expectations and perceptions are associated and together predict early parenting ...
Alithe L. Van den Akker   +4 more
doaj   +1 more source

Attitudes about Stay-At-Home Fathers [PDF]

open access: yes, 2010
Research has shown that stay-at-home fathers are evaluated more negatively than stay-at-home mothers (Rosenwasser, Gonzalez, and Adams 1985; Kroska 2001) and working parents (Brescoll and Uhlmann 2005). Stay-at-home fathers who are also breadwinners have
Rouleau, Tanya
core   +2 more sources

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