Results 31 to 40 of about 557,737 (267)

Bi-level Hybrid Uncertainty Quantification in Fatigue Analysis: S-N Curve Approach

Fracture and Structural Integrity, 2020
Due to its physical complexity, fatigue phenomenon inherently presents a significant number of uncertain parameters to be predicted. In uncertainty quantification (UQ), research has demonstrated that even a small variation in uncertain input quantities ...
R. B. P. Nonato
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Analysis and design of friction stir welding tool

Journal of the Mechanical Behavior of Materials, 2016
Since its inception no one has done analysis and design of FSW tool. Initial dimensions of FSW tool are decided by educated guess. Optimum stresses on tool pin have been determined at optimized parameters for bead on plate welding on AZ31B–O Mg alloy ...
Jagadeesha C.B.
doaj   +1 more source

Numerical Investigation of Fatigue Behavior of Non-patched and Patched Aluminum/Composite Plates

European Mechanical Science, 2021
In this study, the fatigue behavior of composite patched and non-patched Al 5083 aluminum plates was numerically investigated. Al 5083 Aluminum plates with semi-circular notched (2, 3 and 4 mm long cracked) and "V" notched (30°, 45° and 60° angled) were ...
Hamit Adin, Zeyni Sağlam, Mehmet Şükrü Adin   +2 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Fatigue Damage Characteristics of Offshore Wind Power Large-Diameter Monopile Structures During Driving Process

南方能源建设
[Objective] Large-diameter monopile foundations are widely used in marine engineering in China and are typically installed through penetration. Due to the impact of the pile hammer, the pile body experiences continuous impact loads during the driving ...
Tao CHEN, Ruilin DING, Wei GUO, Junhui SHE, Weichao LI   +4 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

A simulation study on strength and fatigue analysis of hydraulic excavator buckets

Frontiers in Mechanical Engineering
The bucket of industrial hydraulic excavator is one of the key components in the excavator. Considering the poor model construction ability of the current bucket strength and fatigue simulation method of industrial hydraulic excavator, which leads to the
Wenbin Pan
doaj   +1 more source