Results 131 to 140 of about 5,122 (217)

Effect of Laser Posterior Nasal Neurolysis for the Treatment of Chronic Rhinitis: A Randomized Controlled Trial

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background To determine the safety and efficacy of laser ablation of the posterior nasal nerve (PNN) for the treatment of chronic rhinitis. Methods This study was a single‐center, prospective, single‐blinded, randomized sham‐controlled trial. Patients with a 24‐h reflective Total Nasal Symptom Score (rTNSS) ≧ 5, rhinorrhea ≧ 2, and congestion ≧
Jyun‐Yi Liao   +9 more
wiley   +1 more source

The Clinical Spectrum and Neurodevelopmental Pathogenesis of KPTN‐Related Disorder in a Mouse Model

open access: yesAnnals of Neurology, EarlyView.
Objective Pathogenic variants in Kaptin (KPTN) cause KPTN‐related disorder (KRD). KPTN modulates mTOR signaling activation within the KICSTOR complex in response to cellular amino acid levels. We define the clinical spectrum and investigate the developmental pathogenesis of KRD.
Lettie E. Rawlins   +104 more
wiley   +1 more source

Dissipatively Fueled Unidirectionally Communicating DNA Circuits That Control Biocatalysis

open access: yesAngewandte Chemie, EarlyView.
Unidirectionally communicating, out‐of‐equilibrium DNA circuits are used to control enzyme activity. Transient DNAzyme activation generates fuel for temporal trypsin activation. Cyclic fuel‐driven hybridization and exonuclease‐mediated reset enable precise control over lifetimes, which is analyzed using combined experimental and computational ...
Philippe Jung   +6 more
wiley   +2 more sources

Translating Biomedical Research to Medical Devices: A Practical Guide and the Arteriovenous Graft Case Study

open access: yesAdvanced NanoBiomed Research, EarlyView.
Despite significant advances, most academic research fails to result in medical products that benefit patients. This guide shares five key steps to help researchers close that gap: set clear goals, test thoroughly, protect ideas, build diverse teams, and partner with industry.
Cristina Oldani   +4 more
wiley   +1 more source

Oxygen‐Acceptor‐Driven High Photochromic Contrast Solid‐State Excited‐State Intramolecular Proton Transfer Photoswitches

open access: yesAngewandte Chemie, EarlyView.
The excited‐state intramolecular proton transfer (ESIPT) photoswitch tpmSA, which features an oxygen−acceptor, exhibits higher photochromic contrast (ΔE*Lab>74) than its nitrogen‐acceptor Schiff base analogues (ΔE*Lab<30). Theoretical calculations indicate that tpmSA effectively suppresses GSIPT, thereby enhancing the contrast.
Yahui Chen   +10 more
wiley   +2 more sources

Failure Analysis of Gear on Rail Transit. [PDF]

open access: yesMaterials (Basel)
Pan AX   +6 more
europepmc   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

open access: yesAdvanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari   +5 more
wiley   +1 more source

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