Results 181 to 190 of about 1,267,081 (283)

Population Pharmacokinetics and Exposure‐Response Analyses to Support Cofetuzumab Pelidotin (ABBV‐647) Dose Optimization in Non‐Small Cell Lung Cancer Patients

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Cofetuzumab pelidotin (Cofe‐P) is an anti‐protein tyrosine kinase 7 (PTK7) antibody‐drug conjugate (ADC) being investigated for the treatment of adults with PTK7‐expressing, recurrent non‐small cell lung cancer (NSCLC). The first‐in‐human (FIH) trial demonstrated tolerability of dosages ≤ 2.8 mg/kg once every 3 weeks (Q3W) and ≤ 3.2 mg/kg Q2W ...
Carla Biesdorf   +8 more
wiley   +1 more source

Thermal‐induced fracture evolution and acoustic signature of Beishan granite: Insights into tensile strength of barrier system for high‐level radioactive waste disposal

open access: yesDeep Underground Science and Engineering, EarlyView.
The tensile strength of granite, a proposed host for nuclear waste, degrades severely above 400°C. We link this to specific microcracking patterns captured by acoustic emission, establishing a scientific basis for assessing repository safety under thermal load.
Wei Zeng   +7 more
wiley   +1 more source

Mitigating surcharge‐induced column‐head cracking in double‐deck shield tunnels using hyperelastic bearing joints

open access: yesDeep Underground Science and Engineering, EarlyView.
A staged three‐dimensional nonlinear soil–structure interaction (SSI) model is established, in which the initial geostress state, tunnel excavation, lining installation, delayed activation of the internal frame, and subsequent surcharge loading are simulated sequentially.
Xinyu Liu   +3 more
wiley   +1 more source

Flexible Direct‐Conversion X‐Ray Detectors: From Emerging Materials to Conformal Imaging

open access: yesENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This comprehensive review analyzed the performance, challenges, and future directions of four emerging material systems for next‐generation flexible direct‐conversion X‐ray detectors: organic semiconductors, perovskites, metal–organic frameworks, and inorganic metal compounds.
Haipeng Di   +11 more
wiley   +1 more source

Harnessing Thin‐Film Solid‐State Electrolytes: Enabling Breakthroughs in All‐Solid‐State Batteries

open access: yesENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Schematic illustration highlighting the advantages of transitioning from traditional thick solid‐state electrolytes (SSEs) to thin‐film SSEs. Thinning the electrolyte enables higher ionic conductivity, reduced interfacial polarization, improved flexibility, compact electrode contact, and enhanced energy density, offering a promising pathway toward high‐
Yitao He   +3 more
wiley   +1 more source

Polyimide Regulated by Molecular Engineering Exhibits Excellent High‐Temperature Energy Storage Performance

open access: yesENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Comprehensive performance analysis chart. Under high temperature and high electric field, the excitation and migration of electrons in polymer dielectrics are significantly accelerated, resulting in a sharp increase in conduction loss and a deterioration of breakdown performance.
Dongyu Hou   +9 more
wiley   +1 more source

Artificial Intelligence in Ophthalmology: From Methodological Advances to Clinical Translation and Future Directions

open access: yesEye &ENT Research, EarlyView.
ABSTRACT Artificial intelligence (AI) is reshaping ophthalmology from task‐specific image analysis toward multimodal, longitudinal, and clinically integrated decision support. This narrative review summarizes the methodological evolution of ophthalmic AI, including traditional machine learning, task‐specific deep learning, self‐supervised learning ...
Yuxin Liu, Hanruo Liu
wiley   +1 more source

From Lived Experience to Digital Advocacy: Eating Disorder Recovery Content Creation on Social Media

open access: yesEuropean Eating Disorders Review, EarlyView.
ABSTRACT Objective Despite the importance of incorporating individuals with lived experience in the collaborative development and delivery of eating disorder (ED) services, a paucity of research has addressed the role of content creators with lived experience within the context of social media in contributing to help‐seeking and recovery spaces.
Albano Gaia   +6 more
wiley   +1 more source

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