Results 91 to 100 of about 3,609,848 (355)
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Thermomechanical fatigue crack initiation in disc alloys using a damage approach
MATEC Web of Conferences, 2018 A fatigue crack initiation model based on damage accumulation via a fatigue memory surface in conjunction with a plastic strain energy parameter was evaluated for thermomechanical fatigue loading in a gas turbine disc alloy.
Leidermark Daniel +4 more
doaj +1 more source
Arthritis Care &Research, EarlyView.Objective We aimed to test the efficacy of personalized treatment of older veterans with chronic low back pain (CLBP) delivered by Aging Back Clinics (ABCs) as compared with usual care (UC). Methods Two hundred ninety‐nine veterans aged 65 to 89 with CLBP from three Veterans Affairs (VA) medical centers underwent baseline testing, randomization to ABC ...
Debra K. Weiner +9 more
wiley +1 more source
Tensile strength of composite sheets with unidirectional stringers and crack-like damage [PDF]
, 1984 The damage tolerance characteristics of metal tension panels with riveted and bonded stringers are well known. The stringers arrest unstable cracks and retard propagation of fatigue cracks.
Poe, C. C., Jr.
core +2 more sources
PE-HD fatigue damage accumulation under variable loading based on various damage models
eXPRESS Polymer Letters, 2017 Despite numerous studies on fatigue of polymer materials under variable loading, there is little work on highdensity polyethylene (PE-HD). In this context, an experimental analysis for determining the fatigue strength of PE-100, under constant and ...
M. Bourchak, A. Aid
doaj +1 more source
Arthritis Care &Research, EarlyView.Objective A patient‐centered approach for chronic disease management, including systemic lupus erythematosus (SLE), aligns treatment with patients’ values and preferences, leading to improved outcomes. This paper summarizes how patient experiences, perspectives, and priorities informed the American College of Rheumatology (ACR) 2024 Lupus Nephritis (LN)
Shivani Garg +20 more
wiley +1 more source
Simulation of Near-Tip Crack Behaviour and Its Correlation to Fatigue Crack Growth with a Modified Strip-Yield Model [PDF]
, 2008 A modified strip-yield model has been developed to simulate the plasticity-induced crack closure under the constant amplitude (CA) and a single overload loading conditions.
Chen, Y.K., Tiu, W., Wang, L., Xu, Y.
core +1 more source
Arthritis Care &Research, EarlyView.Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo +88 more
wiley +1 more source
Differential continuum damage mechanics models for creep and fatigue of unidirectional metal matrix composites [PDF]
Three multiaxial isothermal continuum damage mechanics models for creep, fatigue, and creep/fatigue interaction of a unidirectional metal matrix composite volume element are presented, only one of which will be discussed in depth.
Arnold, S. M., Kruch, S.
core +1 more source
Fatigue life prediction method of carbon fiber-reinforced composites
e-PolymersThe use of composite laminates is characterized by problems such as poor inter-layer bonding and susceptibility of material properties to fatigue cracking, which seriously threaten structural safety. Research on fatigue damage characteristics and fatigue
Lai Jiamei +5 more
doaj +1 more source