Results 71 to 80 of about 500,116 (309)

Neuropsychiatric Symptoms Mimicking Dementia in a Patient Treated With Imatinib

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Tyrosine kinase inhibitors are the cornerstone of chronic myeloid leukemia treatment. Newer agents have more potency and a broader spectrum of action, but also a higher potential for neuropsychiatric side effects. We present a case of a patient on imatinib who developed progressive cognitive, mood, and behavioral alterations.
Ashley Jones, Samuele Bonomi, Keith E. Stockerl‐Goldstein, Randall J. Bateman   +3 more
wiley   +1 more source

Low Stress Level and Low Stress Amplitude Fatigue Loading Simulation of Concrete Components Containing Cold Joints under Fatigue Loading

Applied Sciences
Concrete linings containing cold joint defects may crack or detach under the aerodynamic fatigue loading generated by high-speed train operation, which posing a serious threat to the normal operation of high-speed trains.
He-Lin Fu, Huang-Shi Deng, Yi-Min Wu, Yi-Bo Zhao, Cheng-Da Xie   +4 more
doaj   +1 more source

Low-velocity impact response of friction riveted joints for aircraft application

Materials & Design, 2020
In this paper, the sensitivity of carbon fiber reinforced polyether-ether-ketone (CF-PEEK) friction riveted joints to impact damage was assessed as well as the damage propagation during fatigue and quasi-static mechanical testing.
N.Z. Borba, J. Körbelin, B. Fiedler, J.F. dos Santos, S.T. Amancio-Filho   +4 more
doaj   +1 more source

Clinically Relevant Outcome Measures in Women With Adrenoleukodystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Adrenoleukodystrophy is a rare inherited peroxisomal disease caused by pathogenic variants in the ABCD1 gene located on the X chromosome. Although the most severe central nervous system and adrenal complications typically affect only men with adrenoleukodystrophy, the majority of women develop myeloneuropathy symptoms in adulthood.
Chenwei Yan, Elizabeth I. Pierpont, Amena S. Fine, Reena V. Kartha   +3 more
wiley   +1 more source

Equivalent Fatigue Constitutive Model Based on Fatigue Damage Evolution of Concrete

Applied Sciences
Concrete structures such as bridge decks and road pavements are subjected to repetitive loading and are susceptible to fatigue failure. A simplified stress–strain analysis method that can simulate concrete behavior with a sound physical basis, acceptable
Huating Chen, Zhenyu Sun, Xianwei Zhang, Wenxue Zhang   +3 more
doaj   +1 more source

Fatigue damage in cross-ply titanium metal matrix composites containing center holes [PDF]

The development of fatigue damage in (0/90) sub SCS-6/TI-15-3 laminates containing center holes was studied. Stress levels required for crack initiation in the matrix were predicted using an effective strain parameter and compared to experimental results.
Bakuckas, J. G., Jr., Bigelow, C. A., Johnson, W. S.   +2 more
core   +1 more source

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Estimating the fatigue law of asphalt mixtures using a strain sweep test (EBADE test) [PDF]

, 2013
Fatigue characterization of asphalt mixtures is a very important issue. However, existing techniques to that end are expensive and time consuming. For that reason the asphalt technicians have been studying several different methods to reduce the testing ...
Botella Nieto, Ramón, Martínez Reguero, Adriana Haydée, Miró Recasens, José Rodrigo, Pérez Jiménez, Félix Edmundo   +3 more
core  

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Thermomechanical fatigue crack initiation in disc alloys using a damage approach

MATEC Web of Conferences, 2018
A fatigue crack initiation model based on damage accumulation via a fatigue memory surface in conjunction with a plastic strain energy parameter was evaluated for thermomechanical fatigue loading in a gas turbine disc alloy.
Leidermark Daniel, Eriksson Robert, Rouse James P., Hyde Christopher J., Stekovic Svjetlana   +4 more
doaj   +1 more source