Results 201 to 210 of about 406,514 (267)

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

open access: yesAdvanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang   +6 more
wiley   +1 more source

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

open access: yesAdvanced Science, EarlyView.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh   +7 more
wiley   +1 more source

Fatigue hardening and fatigue life

Acta Metallurgica, 1972
Abstract Fatigue is explained on the basis of work-hardening using the ideas of the statistical theory of slip. Work-hardening in copper single crystals was studied under prescribed stress as well as strain amplitudes. A conclusion is drawn that cyclic deformation can be divided into two regions: one in which straining is controlled by “cyclic ...
P.O Kettunen, U.F Kocks
openaire   +1 more source

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