Results 71 to 80 of about 1,070,454 (316)

Life-cycle of fatigue sensitive structures under uncertainty [PDF]

, 2013
Fatigue is the one of the main contributors to problems related to structural safety of civil and marine structures. Life-cycle management (LCM) techniques considering various uncertainties can be used to predict the safe service life of fatigue ...
Frangopol, Dan M., Soliman, Mohamed
core  

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

The moderating role of coping styles on the associations of fatigue with life satisfaction in Chinese nurses: a cross-sectional study

BMC Nursing
Background Fatigue affects nurses negatively and may influence life satisfaction. According to the stress process model, active coping might influence the impact of adverse conditions such as fatigue on well-being measures such as life satisfaction ...
Yuekun Wu, Wen Bo, Mengyao Li, Li Liu, Hui Wu   +4 more
doaj   +1 more source

Fatigue damage model of woven glass-epoxy fabric composite materials

Journal of Materials Research and Technology, 2020
Based on the Stiffness degradation rule of woven glass fiber composite under fatigue loading, a phenomenological fatigue damage model containing two material parameters in which first is directly proportional to the fatigue life and second is inversely ...
Indra Narayan Yadav, Kamal Bahadur Thapa
doaj   +1 more source

MODELLING OF STRESS GRADIENT EFFECT ON FATIGUE LIFE USING WEIBULL BASED DISTRIBUTION FUNCTION [PDF]

, 2013
In the present paper, a new approach is developed in order to take into account the stress gradient effect on fatigue life of structural components. The proposed approach is based on the weakest link concept in which the shape coefficient of the Weibull ...
KAROLCZUK, Aleksander, PALIN-LUC, Thierry   +1 more
core   +3 more sources

Crystal plasticity simulation of the effect of grain size on the fatigue behavior of polycrystalline Inconel 718

, 2018
A microstructure-based model that accounts for the effect of grain size has been developed to study the effect of grain size on the fatigue life of Inconel 718 alloys.
Cruzado, A., LLorca, J., Lucarini, S., Segurado, J.   +3 more
core   +1 more source

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

Fatigue life prediction of asphalt binders under variable loading levels based on dissipated pseudo-strain energy

Case Studies in Construction Materials
Miner’s criterion is popularized to develop the conventional fatigue life prediction model for estimating the service life corresponding to fixed loading level. However, the conventional model makes it difficult to recognize the significant dependency of
Chenze Fang, Hui Li, Zhenxia Li, Yuanzhao Chen, Tengteng Guo   +4 more
doaj   +1 more source

Non-local energy based fatigue life calculation method under multiaxial variable amplitude loadings [PDF]

, 2013
Reliable design of industrial components against high cycle multiaxial fatigue requires a model capable of predicting both stress gradient and load type effects. Indeed, taking into account gradient effects is of prior importance for the applicability of
BÉNABÈS, Jérôme, COCHETEUX, Francis, PALIN-LUC, Thierry, SAINTIER, Nicolas   +3 more
core   +6 more sources