Results 71 to 80 of about 7,338,374 (306)

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source

A new fatigue equation for asphalt mixtures considering loading sequence effects

Case Studies in Construction Materials
The fatigue life of asphalt mixture has been found to significantly depend on loading sequences. However, the widely used traditional linear fatigue equations are difficult to determine the fatigue life of asphalt mixture subjected to different loading ...
Chenze Fang, Deqing Tang, Zhenxia Li, Yuanzhao Chen, Naisheng Guo, Tengteng Guo   +5 more
doaj   +1 more source

The effects of surface defects on the fatigue of water and oil lubricated contacts [PDF]

, 2000
A study into effects of surface defects on the rolling contact fatigue of brass and rail steel has been undertaken on a twin-disc rolling-sliding test machine with both oil and water lubrication.
Gao, N., Dwyer-Joyce, R. S.
core   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

Characterising the impact of surface integrity on the fatigue behaviour of a shot-peened connecting rod [PDF]

, 2014
The present study focuses on analysing and modelling the influence on fatigue behaviour of the surface of a hot-forged C70 connecting rod which undergoes a shot-blasting treatment.
PESSARD, Etienne, GERIN, Benjamin, VERDU, Catherine, MOREL, Franck   +3 more
core  

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source

Micro-mechanical modelling of high cycle fatigue behaviour of metals under multiaxial loads [PDF]

, 2012
An analysis of high cycle multiaxial fatigue behaviour is conducted through the numerical simulation of polycrystalline aggregates using the finite elementmethod.
PALIN-LUC, Thierry, MOREL, Franck, SAINTIER, Nicolas, ROBERT, Camille   +3 more
core   +1 more source

Neurologic Manifestations of Long COVID Affect Adult Females More Severely Than Males

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize differences in neurologic manifestations of postacute sequelae of SARS‐CoV‐2 infection (Neuro‐PASC) between females and males. Methods Cross‐sectional study of the first consecutive 261 posthospitalization Neuro‐PASC (PNP) and 2068 nonhospitalized Neuro‐PASC (NNP) patients evaluated at the Neuro‐COVID clinic between ...
Hannah Kopinsky, Melissa Lopez, Janet Miller, Millenia Jimenez, Eric M. Liotta, Igor J. Koralnik   +5 more
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

A Fatigue Life Prediction Model Based on Modified Resolved Shear Stress for Nickel-Based Single Crystal Superalloys

Metals, 2019
In this paper, the viewpoint that maximum resolved shear stress corresponding to the two slip systems in a nickel-based single crystal high-temperature fatigue experiment works together was put forward.
Jialiang Wang, Dasheng Wei, Yanrong Wang, Xianghua Jiang   +3 more
doaj   +1 more source