Results 51 to 60 of about 223,101 (311)

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Improved numerical model for fatigue cumulative damage of mechanical structure considering load sequence and interaction

Advances in Mechanical Engineering, 2021
To more accurately predict the fatigue life of components under the action of random loads, it is necessary to explore the influence of the interaction between the load sequence and the load on the life prediction.
Bixiong Huang, Shuci Wang, Shuanglong Geng, Xintian Liu   +3 more
doaj   +1 more source

Life prediction of materials exposed to monotonic and cyclic loading: A technology survey and bibliography [PDF]

, 1975
Announced survey directs attention toward low cycle fatigue and thermal fatigue experienced at elevated temperatures equivalent to those found in hot end of gas turbine engine.
Carpenter, J. L., Jr., Mandel, G., Moya, N., Stuhrke, W. F.   +3 more
core   +1 more source

Predicting the Fatigue Life of a Ball Joint

Transport and Telecommunication Journal, 2021
Abstract The technical conditions and service life of steering elements of vehicles are an important factor directly affecting road safety. Therefore, high reliability of such kind’s components is required. In the paper, on the basis of the stand test, the fatigue durability of a ball joint of a steering tie rod is determined.
Edward Kozłowski, Anna Borucka, Tadeusz Szymczak, Andrzej Świderski, Leszek Gil   +4 more
openaire   +2 more sources

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe   +16 more
wiley   +1 more source

Life-cycle of fatigue sensitive structures under uncertainty [PDF]

, 2013
Fatigue is the one of the main contributors to problems related to structural safety of civil and marine structures. Life-cycle management (LCM) techniques considering various uncertainties can be used to predict the safe service life of fatigue ...
Frangopol, Dan M., Soliman, Mohamed
core  

Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions. We aimed to characterize symptom profiles, diagnostic trends, provider involvement, and treatment patterns in vestibular disorders.
Ali Rafati, Sami I. Nassar, Shaun A. Nguyen, Patricia L. Gerend, Michael C. Schubert, Michael T. Teixido, Frederick A. Godley, Joel A. Goebel, Cynthia A. Ryan, Habib G. Rizk, Amir Kheradmand   +10 more
wiley   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

A Novel Physics-Guided Neural Network for Predicting Fatigue Life of Materials

Applied Sciences
A physics-guided neural network (PGNN) is proposed to predict the fatigue life of materials. In order to reduce the complexity of fatigue life prediction and reduce the data required for network training, the PGNN only predicts the fatigue performance ...
Dexin Yang, Afang Jin, Yun Li
doaj   +1 more source

MODIFICATION METHOD OF STRAIN-LIFE CURVES UNDER DIFFERENT SURFACE CONDITIONS OF COMPONENTS (MT)

Jixie qiangdu, 2022
Based on the practical problem of fatigue life prediction of landing gear, the fatigue life prediction model of landing gear components with surface treatment was studied.
DUAN Heng, LIU PangLun, JIANG BingYan, SHE ShiQiang, LOU Rui   +4 more
doaj