Results 121 to 130 of about 69,238 (318)

Simulation of thermomechanical fatigue of ductile cast iron and lifetime calculation

, 2015
In this paper, both standard and constrained thermomechanical fatigue (TMF) tests were conducted on a high silicon ductile cast iron (DCI). The standard TMF tests were conducted with independent control of mechanical strain, out-of-phase (OP) and in ...
Quan, Guangchun, Zhang, Zhong, Liu, Xiaoyang, Sloss, Clayton, Wu, Xijia   +4 more
core   +1 more source

Psychiatric and Cognitive Features in Italian Women With the FMR1 Premutation: A Comprehensive Assessment Using SCID‐5 and Standardized Cognitive Measures

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Women with the FMR1 premutation (PM) are at increased risk for fragile X‐associated conditions (FXPAC), including cognitive and psychiatric features collectively termed fragile X‐associated neuropsychiatric disorders (FXAND). This study is the first to systematically investigate cognitive and psychiatric features in Italian female premutation ...
Federica Alice Maria Montanaro, Randi J. Hagerman, Giuseppina Spano, Flora Tassone, Giancarlo Logroscino, Andrea Bosco   +5 more
wiley   +1 more source

Probabilistic Lifetime Predictions Using Total Stress Concept, Remote Monitoring and Global Wave Forecast Models: Fatigue Analysis of Damen’s FCS5009 Vessels

, 2019
At Damen’s Research and Development department, continuous improvements are made to existing design practices using recent technological developments and fatigue design is currently on the anvil. High speed craft operating around the globe are subject to
Bapat, Advait (author)
core  

Toward Chromoselective Transformations in Biological Systems: Perspectives and Challenges

Angewandte Chemie International Edition, EarlyView.
Controlling biological systems with small‐molecule chromophores has evolved into a powerful strategy and is applied from chemical biology to medicine. However, the complexity of in vivo systems cannot be matched by a single wavelength of light. Developing methods to combine and individually control multiple chromophores is crucial.
Nadja A. Simeth
wiley   +1 more source

Fatigue-life predictions including the effects of hold time and multiaxial loads on crack-coalescence behaviour

, 2000
Two aspects of crack-coalescence behavior are reported. The first concerns a regime frequently referred to in the literature as creep-fatigue interactions but which in this paper is essentially a time-dependent, fatigue-failure process.
Miller, K. J., Gao, N., Brown, M.W.
core   +1 more source

Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults

Autism Research, EarlyView.
ABSTRACT Irritability is a prevalent and impairing feature associated with autism, yet remains poorly understood, particularly in adults. Drawing heavily on insights translated from pediatric and transdiagnostic literatures, we propose that irritability in autistic individuals often reflects a psychophysiological stress or threat response, rooted in a ...
Hsiang‐Yuan Lin, Arthur N. Westover, Amy S. F. Lutz, Manish K. Jha   +3 more
wiley   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

A methodology for fatigue lifetime prediction of functional mechanical metamaterials

Engineering Failure Analysis
While several studies have experimentally investigated the fatigue behavior of polymeric metamaterials, systematic methodologies for predicting their fatigue lifetime are still lacking. Therefore, this paper proposes and experimentally validates a comprehensive methodology for fatigue lifetime prediction of polymeric mechanical metamaterials.
Lukáš Trávníček, Petra Helešicová, Mathias Fleisch, Jan Poduška, Michael Berer, Gerald Pinter, Pavel Hutař   +6 more
openaire   +1 more source

RETRACTED: Learner emotions and performance in hypercasual VR games with adaptive AI difficulty

British Educational Research Journal, EarlyView.
Abstract Hypercasual virtual reality games (HVRGs) are widely regarded as cost‐effective tools for rapid skill acquisition, yet the mechanisms that optimise their effectiveness and user acceptance remain insufficiently explored. This mixed‐methods empirical study investigates how playful emotions, characterised by engagement, enjoyment and anxiety ...
Zeeshan Ahmed, Faizan Ahmad, Chen Hui
wiley   +1 more source