Results 81 to 90 of about 16,642,961 (356)

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Quasi-Static and Fatigue Strength of Copper-Brazed Stainless Steel

Applied Sciences
This study investigates the quasi-static and fatigue strength of copper-brazed 316L stainless steel. Quasi-static and fatigue tests were conducted at room temperature (20 °C) using a Zwick/Roell Vibrophore 100 testing machine and specially designed ...
Srečko Glodež, Tonica Bončina, Žan Dvoršak, Branko Nečemer, Franc Zupanič   +4 more
doaj   +1 more source

Mechanics of fretting fatigue tests

International Journal of Mechanical Sciences, 1987
A popular fretting fatigue test, in which oscillating tension is applied in phase with the fretting force, is analyzed. The configuration is a generalization of the well-known Mindlin contact problem, and it is shown that the addition of bulk tension has a substantial effect on the stick- slip geometry and the shear traction at the interface.
Nowell, D, Hills, D
openaire   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Tensile and Fatigue Performance of Cold-Work Tool Steels for Adjustable Forming Tools

Applied Sciences
Forming tools adjustable by tensile elastic deformations offer opportunities for improved process control and reduced wear in high-volume metal forming processes such as ironing.
Kaarel Siimut, Kasper Mygind Madsen, Ermanno Ceron, Chris Valentin Nielsen   +3 more
doaj   +1 more source

Improved resonance method for fatigue test of full-scale wind turbine blades

AIP Advances, 2022
To further reduce the power of exciter in the common fatigue testing methods and increase the testing frequency to decrease the fatigue testing time, this paper proposes an improved fatigue testing method—Tug Fatigue Testing system (TFTs). The advantages
Aiguo Zhou, Jinlei Shi, Yi Ma, Xiufeng Xu   +3 more
doaj   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Efficient Reconstruction of High-Resolution Tidal Turbine Blade Deflection and Strain Maps Through Sensing Location Optimisation

Journal of Marine Science and Engineering
During fatigue tests of tidal turbine blades, digital image correlation (DIC) is used to collect vital information about the specimen. DIC provides high-resolution displacement and strain maps of selected blade sections; however, continuous operation is ...
Marek J. Munko, Miguel A. Valdivia Camacho, Fergus Cuthill, Conchúr M. Ó Brádaigh, Sergio Lopez Dubon   +4 more
doaj   +1 more source

Surface characterization and influence of anodizing process on fatigue life of Al 7050 alloy [PDF]

, 2011
The present study investigates the influence of anodizing process on fatigue life of aluminium alloy 7050-T7451 by performing axial fatigue tests at stress ratio ‘R’ of 0.1.
Chaussumier, Michel, Chieragatti, Rémy, Mabru, Catherine, Rezaï-Aria, Farhad, Shahzad, Majid   +4 more
core   +3 more sources

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe   +16 more
wiley   +1 more source