Results 71 to 80 of about 628,870 (287)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Liver glutathione depletion after preservation and reperfusion in human liver transplantation Depleção da glutationa hepática após preservação e reperfusão no transplante de fígado em humanos

Acta Cirúrgica Brasileira, 2006
PURPOSE: The oxidative stress is an important mechanism responsible for dysfunction after orthotopic liver transplantation (OLT). Glutathione (GSH) low levels after cold storage render the grafts vulnerable to reperfusion injury. Aim of this study was to
Tomaz de Jesus Maria Grezzana Filho, Carlos Otávio Corso, Maria Lúcia Zanotelli, Cláudio Augusto Marroni, Ajácio Bandeira Mello Brandão, Eduardo Schlindwein, Ian Leipnitz, Mário Henrique Mattos Meine, Alfeu Fleck Jr., Ricardo Hoppen, Guillermo Kiss, Guido Pio Cracco Cantisani   +11 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Factors related to the presence of large for gestational age newborns in pregnant women with gestational diabetes mellitus [PDF]

, 2009
PURPOSE: to evaluate factors related to the presence of neonatal macrosomia in pregnant women with gestational diabetes mellitus. METHODS: 157 pregnant women presenting gestational diabetes mellitus in follow-up were retrospectively selected from January
Barreto Neto, Lauro, Bertini, Anna Maria, Carvalho, Leonardo Souza De, Melo, Muriel Matias, Ribeiro, Thaís Engel, Silva, Jean Carl   +5 more
core   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Analysis of Ca-PZT powder obtained by the Pechini and partial oxalate methods Análise do pó de PZT-Ca obtido pelo método Pechini e método do oxalato parcial

Cerâmica, 2008
Ca-Pb(Zr,Ti)O3 (Ca-PZT) powders were prepared by a combined method, Pechini technique for the intermediate ZrTiO4 (ZT) particles and oxalate route for the final powder.
R. S. Nasar, M. Cerqueira, E. Longo, J. A. Varela   +3 more
doaj   +1 more source

Seismic moment tensors for six events in the Minto Flats fault zone, 2012-2016 [PDF]

, 2018
Using seismic waveform data, we determine seismic moment tensor solutions for six events in the Minto Flats fault zone, 2012-2016.This project was supported by the National Science Foundation, Grant EAR ...
Silwal, Vipul
core  

Association between high dietary intake of the n-3 polyunsaturated fatty acid docosahexaenoic acid and reduced risk of Crohn's disease [PDF]

, 2014
Background: There are plausible mechanisms for how dietary docosahexaenoic acid (DHA), an n−3 polyunsaturated fatty acid, could prevent Crohn's disease (CD).
Abraham, Ananthakrishnan, Ananthakrishnan, Ananthakrishnan, Arita, Bartoli, Belluzzi, Bingham, Burdge, Chan, Charpentier, Corey, Depner, Feagan, Fritsche, Goldbohm, Goldman, Hommes, Jostins, Kaaks, Levy, Novak, Rao, Riboli, Rodriguez-Lagunas, Sakamoto, Salem, Samuelsson, Serhan, Serini, Shivananda, Tjonneland, Turner, Watanabe, Weylandt, Yaqoob   +35 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

A INFLUÊNCIA DO TREINAMENTO AERÓBIO E ANAERÓBIO NA PERFORMANCE DO PILOTO DE CAÇA

Revista de Educação Física, 2017
Desde o desenvolvimento dos modernos caças, de alta performance, capazes de atingirem altas e sustentadas forças de aceleração, o problema da tolerância humana tem se tornado de maior importância.
André Osvaldo Brandão Guimarães
doaj