Expression of recombinant G-CSF receptor domains and their inhibitory role on G-CSF function
Research in Pharmaceutical Sciences, 2020 Background and purpose: Granulocyte colony-stimulating factor (G-CSF) is routinely used in combination with chemotherapy to battle neutropenia. However, studies suggest that this chemokine may increase the risk of metastasis and malignancy in many ...
Hamid Bakherad +9 more
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Stem Cell Mobilization with G-CSF versus Cyclophosphamide plus G-CSF in Mexican Children [PDF]
Stem Cells International, 2016 Fifty-six aphaereses were performed in 23 pediatric patients with malignant hematological and solid tumors, following three different protocols for PBPC mobilization and distributed as follows: A: seventeen mobilized with 4 g/m2 of cyclophosphamide (CFA)
José Eugenio Vázquez Meraz +4 more
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Exploring innovative G-CSF schedules in AML cytarabine-based consolidation through a digital twin study of white blood cell recovery. [PDF]
PLoS ONEPatients with acute myeloid leukemia (AML) are at high risk for life-threatening infectious complications due to chemotherapy-induced leukopenia. In contrast to other malignancies, prophylactic administration of granulocyte colony-stimulating factors (G ...
Adrian-Manuel Reimann +4 more
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Distribution and clinicopathological characteristics of G-CSF expression in tumor cells and stromal cells in upper tract urothelial carcinoma [PDF]
Journal of Cancer Research and Clinical OncologyBackground Urothelial carcinoma (UC) is a common type of malignant disease; however, the diagnostic and prognostic markers of upper urinary tract urothelial cancer (UTUC) remain poorly understood because of its rarity.
Go Kobayashi +7 more
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G-CSF or not G-CSF? That is the question [PDF]
Bone Marrow Transplantation, 2004 Although administration of myeloid colony-stimulating factors (G-CSF or GM-CSF) has been routinely used to increase the rate of neutrophil recovery, evidence suggests that clinical efficacy in the transplant setting is doubtful (Table 1). We performed two consecutive prospective randomized trials to assess the use of G-CSF (filgrastim) after autologous
M A Canales, F Hernández-Navarro
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Hematopoietic properties of granulocyte colony-stimulating factor/immunoglobulin (G-CSF/IgG-Fc) fusion proteins in normal and neutropenic rodents. [PDF]
PLoS ONE, 2014 Previously we showed that granulocyte colony-stimulating factor (G-CSF) in vitro bioactivity is preserved when the protein is joined via a flexible 7 amino acid linker to an immunoglobulin-1 (IgG1)-Fc domain and that the G-CSF/IgG1-Fc fusion protein ...
George N Cox +5 more
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Endogenous Expression of G-CSF in Rat Dorsal Root Ganglion Neurons after Nerve Injury
Brain Sciences, 2021 Granulocyte colony-stimulating factor (G-CSF) has been reported to modulate pain function following nerve injury. However, the expression of endogenous G-CSF in the dorsal root ganglion (DRG) and the response to nerve injury remain unclear.
Chun-Chang Yeh +5 more
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Frontiers in Bioengineering and Biotechnology, 2020 Currently, amino-terminal PEGylated human granulocyte colony stimulating factor (huG-CSF) is used to prevent and treat neutropenia. Although huG-CSF has been used as a drug for more than 20 years, it has three significant drawbacks: (i) it relies on PEG ...
Monika Kumari, Girish Sahni, Sonal Datta
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Characterization and In Silico Analysis of The Structural Features of G-CSF Derived from Lysates of Escherichia coli [PDF]
Cell Journal, 2019 Objective: Granulocyte colony-stimulating factor (G-CSF) has a wide variety of functions including stimulation of hematopoiesis and proliferation of granulocyte progenitor cells.
Sharareh Peymanfar +4 more
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G-CSF, the guardian of granulopoiesis
Seminars in Immunology, 2021 A considerable amount of continuous proliferation and differentiation is required to produce daily a billion new neutrophils in an adult human. Of the few cytokines and factors known to control neutrophil production, G-CSF is the guardian of granulopoiesis.
Hrishikesh M. Mehta, Seth J. Corey
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