Exploring innovative G-CSF schedules in AML cytarabine-based consolidation through a digital twin study of white blood cell recovery. [PDF]
PLoS ONEPatients with acute myeloid leukemia (AML) are at high risk for life-threatening infectious complications due to chemotherapy-induced leukopenia. In contrast to other malignancies, prophylactic administration of granulocyte colony-stimulating factors (G ...
Adrian-Manuel Reimann +4 more
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Expression of recombinant G-CSF receptor domains and their inhibitory role on G-CSF function
Research in Pharmaceutical Sciences, 2020 Background and purpose: Granulocyte colony-stimulating factor (G-CSF) is routinely used in combination with chemotherapy to battle neutropenia. However, studies suggest that this chemokine may increase the risk of metastasis and malignancy in many ...
Hamid Bakherad +9 more
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Hematopoietic properties of granulocyte colony-stimulating factor/immunoglobulin (G-CSF/IgG-Fc) fusion proteins in normal and neutropenic rodents. [PDF]
PLoS ONE, 2014 Previously we showed that granulocyte colony-stimulating factor (G-CSF) in vitro bioactivity is preserved when the protein is joined via a flexible 7 amino acid linker to an immunoglobulin-1 (IgG1)-Fc domain and that the G-CSF/IgG1-Fc fusion protein ...
George N Cox +5 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2020 Currently, amino-terminal PEGylated human granulocyte colony stimulating factor (huG-CSF) is used to prevent and treat neutropenia. Although huG-CSF has been used as a drug for more than 20 years, it has three significant drawbacks: (i) it relies on PEG ...
Monika Kumari, Girish Sahni, Sonal Datta
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Endogenous Expression of G-CSF in Rat Dorsal Root Ganglion Neurons after Nerve Injury
Brain Sciences, 2021 Granulocyte colony-stimulating factor (G-CSF) has been reported to modulate pain function following nerve injury. However, the expression of endogenous G-CSF in the dorsal root ganglion (DRG) and the response to nerve injury remain unclear.
Chun-Chang Yeh +5 more
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Characterization and In Silico Analysis of The Structural Features of G-CSF Derived from Lysates of Escherichia coli [PDF]
Cell Journal, 2019 Objective: Granulocyte colony-stimulating factor (G-CSF) has a wide variety of functions including stimulation of hematopoiesis and proliferation of granulocyte progenitor cells.
Sharareh Peymanfar +4 more
doaj +1 more source
Ciência Rural, 2007 As neutropenias persistentes podem ser decorrentes de alterações na granulopoiese, causadas por efeitos supressivos ou tóxicos à medula óssea, predispõem o paciente a infecções comprometendo sua sobrevida.
Cynthia de Assumpção Lucidi +1 more
doaj +1 more source
Regulation of the bone marrow microenvironment by G-CSF: Effects of G-CSF on acute lymphoblastic leukaemia. [PDF]
PLoS ONE, 2017 It has been suggested that disruption of the lymphoid niche by G-CSF may be of therapeutic benefit to patients with acute lymphoblastic leukaemia. We used a xenograft model to determine the effect of G-CSF on ALL progression in a minimal residual disease
Jordan Basnett +4 more
doaj +1 more source
Application of G-CSF in high-leukocyte acute myeloid leukemia is a poor prognostic factor
Hematology, 2023 Objective To analyze the effect of granulocyte colony-stimulating factor (G-CSF) on outcomes in patients with acute myeloid leukemia (AML).Methods A total of 526 patients with AML in the Haematology Department were enrolled.
Ping Weng +5 more
doaj +1 more source
Journal of Patient-Reported Outcomes, 2021 Background Several options for granulocyte colony-stimulating factor (G-CSF) prophylaxis of chemotherapy-induced febrile neutropenia are available to patients worldwide.
Aylin Yucel +5 more
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