Results 31 to 40 of about 269,290 (261)

On-demand plerixafor added to high-dose cyclophosphamide and pegylated recombinant human granulocyte colony-stimulating factor in the mobilization of patients with multiple myeloma: a treatment with high effectiveness, convenient, and affordable cost

Frontiers in Oncology
ObjectiveThe combination of high-dose cyclophosphamide (HD-Cy) (3g/m2) plus granulocyte colony-stimulating factor (G-CSF) and on-demand plerixafor (PXF) has been considered an effective mobilization regimen of patients with multiple myeloma(MM). However,
Li-qiong Hou, Jun-Ru Liu, Jing-Li Gu, Mei-Lan Chen, Li-Fen Kuang, Bei-Hui Huang, Wai-yi Zou, Juan Li   +7 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Molecular Cloning, Expression and Purification of G-CSF Isoform D, an Alternative Splice Variant of Human G-CSF

Iranian Journal of Allergy, Asthma and Immunology, 2019
Granulocyte colony-stimulating factor (G-CSF) is the major regulator of hemopoiesis and granulopoiesis. However, overexpression of G-CSF has been implicated in several important processes in tumor biology such as tumor growth, angiogenesis, and ...
Fatemeh Sadat Toghraie, Mahsa Yazdanpanah-Samani, Elham Mahmoudi Maymand, Ahmad Hosseini, Amir Asgari, Amin Ramezani, Abbas Ghaderi   +6 more
doaj   +1 more source

Granulocyte colony-stimulating factor attenuates myocardial remodeling and ventricular arrhythmia susceptibility via the JAK2-STAT3 pathway in a rabbit model of coronary microembolization

BMC Cardiovascular Disorders, 2020
Background Coronary microembolization (CME) has a poor prognosis, with ventricular arrhythmia being the most serious consequence. Understanding the underlying mechanisms could improve its management.
Weiwei Wang, Shuhua Ye, Lutao Zhang, Qiong Jiang, Jianhua Chen, Xuehai Chen, Feilong Zhang, Hangzhou Wu   +7 more
doaj   +1 more source

Granulocyte colony‐stimulating factor attenuates liver damage by M2 macrophage polarization and hepatocyte proliferation in alcoholic hepatitis in mice

Hepatology Communications, 2022
Massive inflammation and liver failure are main contributors to the high mortality in alcohol‐associated hepatitis (AH). In recent clinical trials, granulocyte colony‐stimulating factor (G‐CSF) therapy improved liver function and survival in patients ...
Yeonhee Cho, Radhika Joshi, Patrick Lowe, Christopher Copeland, Marcelle Ribeiro, Caroline Morel, Donna Catalano, Gyongyi Szabo   +7 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Development and characterization of a novel fusion protein of a mutated granulocyte colony-stimulating factor and human serum albumin in Pichia pastoris. [PDF]

PLoS ONE, 2014
The purpose of the present work was to develop a novel, long-acting and potent human serum albumin/granulocyte colony stimulating factor (HSA/G-CSF) therapeutic fusion protein.
Yan-Shan Huang, Xiao-Fang Wen, Zhi-Yu Yang, Yi-Liang Wu, You Lu, Lin-Fu Zhou   +5 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

سطح سرمی عوامل محرک کلونی گرانولوسیتی، ماکروفاژی و گرانولوسیتی- ماکروفاژی در خون محیطی بیماران مبتلا به تومور پستان [PDF]

مجله دانشگاه علوم پزشکی سبزوار, 2019
زمینه و هدف: عوامل محرک کلونیگلیکوپروتئین‌هایی هستند که تکثیر و تمایز سلول‌های پیش‌ساز خونساز را در مغز استخوان تحریک میکنند. اما مطالعات متعدد نشان داده اند این فاکتورها می توانند سبب تحریک تکثیر سلولهای غیر خونساز، از جمله سلول‌های سرطانی نیز شوند.
محبوبه رزمخواه, پریسا کریم زاده, فاطمه اقبالی, سمیه رضایی فرد, زهرا فقیه   +4 more
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