Results 31 to 40 of about 12,166,273 (260)

Differential regulation of microglial states by colony stimulating factors

Frontiers in Cellular Neuroscience, 2023
Recent studies have emphasized the role of microglia in the progression of many neurodegenerative diseases. The colony stimulating factors, CSF-1 (M-CSF), granulocyte-macrophage CSF (GM-CSF) and granulocyte CSF (G-CSF) regulate microglia through ...
E. Richard Stanley, Fabrizio Biundo, Şölen Gökhan, Violeta Chitu   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

G-CSF and G-CSFR Modulate CD4 and CD8 T Cell Responses to Promote Colon Tumor Growth and Are Potential Therapeutic Targets

Frontiers in Immunology, 2020
Cytokines are known to shape the tumor microenvironment and although progress has been made in understanding their role in carcinogenesis, much remains to learn regarding their role in tumor growth and progression.
Ioannis Karagiannidis, Stephanie J. Jerman, Damian Jacenik, Damian Jacenik, Brandon B. Phinney, Ruoxin Yao, Eric R. Prossnitz, Ellen J. Beswick   +7 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Molecular Cloning, Expression and Purification of G-CSF Isoform D, an Alternative Splice Variant of Human G-CSF

Iranian Journal of Allergy, Asthma and Immunology, 2019
Granulocyte colony-stimulating factor (G-CSF) is the major regulator of hemopoiesis and granulopoiesis. However, overexpression of G-CSF has been implicated in several important processes in tumor biology such as tumor growth, angiogenesis, and ...
Fatemeh Sadat Toghraie, Mahsa Yazdanpanah-Samani, Elham Mahmoudi Maymand, Ahmad Hosseini, Amir Asgari, Amin Ramezani, Abbas Ghaderi   +6 more
doaj   +1 more source

Granulocyte colony‐stimulating factor attenuates liver damage by M2 macrophage polarization and hepatocyte proliferation in alcoholic hepatitis in mice

Hepatology Communications, 2022
Massive inflammation and liver failure are main contributors to the high mortality in alcohol‐associated hepatitis (AH). In recent clinical trials, granulocyte colony‐stimulating factor (G‐CSF) therapy improved liver function and survival in patients ...
Yeonhee Cho, Radhika Joshi, Patrick Lowe, Christopher Copeland, Marcelle Ribeiro, Caroline Morel, Donna Catalano, Gyongyi Szabo   +7 more
doaj   +1 more source

Data_Sheet_1_Comparison of Neutrophil Function in Granulocyte Concentrates From Prednisone- and G-CSF-Treated Donors: Effect of Stimulant, Leukapheresis and Storage.pdf

, 2022
Transfusion of granulocyte concentrates (GC) is an alternative therapy for neutropenic patients with life-threatening infections. While neutrophils are the main source of antimicrobial activity, only neutrophil numbers are used to certify GCs.
Lucie Boyer (12197054), Myriam Vaillancourt (11001309), Guillaume Paré (84081), Marie-Pierre Cayer (12197057), Donald R. Branch (8463504), Nancy Robitaille (12197063), Marie-Ève Allard (12197051), Patricia Landry (114532), Julien Vitry (11001306), Andréa Murru (11001312), Mélissa Girard (12197066), Marie-Michèle Labrecque (12197060), Maria J. Fernandes (11001321)   +12 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

سطح سرمی عوامل محرک کلونی گرانولوسیتی، ماکروفاژی و گرانولوسیتی- ماکروفاژی در خون محیطی بیماران مبتلا به تومور پستان [PDF]

مجله دانشگاه علوم پزشکی سبزوار, 2019
زمینه و هدف: عوامل محرک کلونیگلیکوپروتئین‌هایی هستند که تکثیر و تمایز سلول‌های پیش‌ساز خونساز را در مغز استخوان تحریک میکنند. اما مطالعات متعدد نشان داده اند این فاکتورها می توانند سبب تحریک تکثیر سلولهای غیر خونساز، از جمله سلول‌های سرطانی نیز شوند.
محبوبه رزمخواه, پریسا کریم زاده, فاطمه اقبالی, سمیه رضایی فرد, زهرا فقیه   +4 more
doaj  

Granulocyte colony-stimulating factor attenuates myocardial remodeling and ventricular arrhythmia susceptibility via the JAK2-STAT3 pathway in a rabbit model of coronary microembolization

BMC Cardiovascular Disorders, 2020
Background Coronary microembolization (CME) has a poor prognosis, with ventricular arrhythmia being the most serious consequence. Understanding the underlying mechanisms could improve its management.
Weiwei Wang, Shuhua Ye, Lutao Zhang, Qiong Jiang, Jianhua Chen, Xuehai Chen, Feilong Zhang, Hangzhou Wu   +7 more
doaj   +1 more source