Results 31 to 40 of about 9,409,602 (307)

The kinetics of G‐CSF folding [PDF]

Protein Science, 2002
AbstractThe folding kinetics of G‐CSF were determined by trp‐fluorescence and far‐UV circular dichroism. Folding and unfolding was achieved by rapid dilution and mixing of the denaturant, GdnHCl. G‐CSF is a four‐helical bundle protein with two long loops between the first and second helices and between the third and fourth helices.
openaire   +2 more sources

G-CSF Prevents the Progression of Structural Disintegration of White Matter Tracts in Amyotrophic Lateral Sclerosis: A Pilot Trial

, 2011
Background: The hematopoietic protein Granulocyte-colony stimulating factor (G-CSF) has neuroprotective and regenerative properties. The G-CSF receptor is expressed by motoneurons, and G-CSF protects cultured motoneuronal cells from apoptosis.
Tobias Warnecke, Schneider, A, Deppe Michael, Floel, A, Thomas Duning, Harald Kugel, Mohammadi Siawoosh, Katja Kolpatzik, Knecht Stefan, Schiffbauer, H, Wolf Rüdiger Schäbitz, Hagen Schiffbauer, Schäbitz Wolf Rüdiger, Duning Thomas, Kugel Harald, Knecht, S, Warnecke Tobias, Agnes Floel, Kolpatzik, K, Warnecke, T, Floel Agnes, Kugel, H, Schabitz, WR, Deppe, M, Kolpatzik Katja, Armin Schneider, Mohammadi, S, Michael Deppe, Duning, T, Schneider Armin, Stefan Knecht, Siawoosh Mohammadi, Schiffbauer Hagen   +32 more
core   +1 more source

Granulocyte colony-stimulating factor attenuates myocardial remodeling and ventricular arrhythmia susceptibility via the JAK2-STAT3 pathway in a rabbit model of coronary microembolization

BMC Cardiovascular Disorders, 2020
Background Coronary microembolization (CME) has a poor prognosis, with ventricular arrhythmia being the most serious consequence. Understanding the underlying mechanisms could improve its management.
Weiwei Wang, Shuhua Ye, Lutao Zhang, Qiong Jiang, Jianhua Chen, Xuehai Chen, Feilong Zhang, Hangzhou Wu   +7 more
doaj   +1 more source

Pathophysiological Roles of G-CSF

Journal of Nutritional Science and Vitaminology, 1992
G-CSF is produced by a variety of cells. In situ hybridization showed that only a small proportion of stromal cells expressed G-CSF after stimulation with LPS or IL-1. The measurement of serum G-CSF level by enzyme immunoassay provided valuable information as to the pathophysiological roles of G-CSF. In aplastic anemia, there was an inverse correlation
OZAWA, K., WATARI, K., TSURUTA, T., TAKAHASHI, S., OGURA, H., YOSHIKUBO, T., NISHIKAWA, M., SHIMANE, M., OKAMOTO, S., TOJO, A., TANI, K., ASANO, S.   +11 more
openaire   +3 more sources

SB203580 increases G-CSF production via a stem-loop destabilizing element in the 3 ' untranslated region in macrophages independently of its effect on p38 MAPK activity

, 2017
Background: Granulocyte-colony stimulating factor (G-CSF) is a major regulator of the production and survival of neutrophils. Regulation of G-CSF expression is complex and occurs at both transcription and post-transcription levels.
Chang, Shwu-Fen;Li, Huai-Ci;Huang, Yu-Pei;Tasi, Wen-Ju;Chou, Yuan-Yi;Lu, Shao-Chun, 呂紹俊   +1 more
core   +1 more source

On-demand plerixafor added to high-dose cyclophosphamide and pegylated recombinant human granulocyte colony-stimulating factor in the mobilization of patients with multiple myeloma: a treatment with high effectiveness, convenient, and affordable cost

Frontiers in Oncology
ObjectiveThe combination of high-dose cyclophosphamide (HD-Cy) (3g/m2) plus granulocyte colony-stimulating factor (G-CSF) and on-demand plerixafor (PXF) has been considered an effective mobilization regimen of patients with multiple myeloma(MM). However,
Li-qiong Hou, Jun-Ru Liu, Jing-Li Gu, Mei-Lan Chen, Li-Fen Kuang, Bei-Hui Huang, Wai-yi Zou, Juan Li   +7 more
doaj   +1 more source

Granulocyte colony‐stimulating factor attenuates liver damage by M2 macrophage polarization and hepatocyte proliferation in alcoholic hepatitis in mice

Hepatology Communications, 2022
Massive inflammation and liver failure are main contributors to the high mortality in alcohol‐associated hepatitis (AH). In recent clinical trials, granulocyte colony‐stimulating factor (G‐CSF) therapy improved liver function and survival in patients ...
Yeonhee Cho, Radhika Joshi, Patrick Lowe, Christopher Copeland, Marcelle Ribeiro, Caroline Morel, Donna Catalano, Gyongyi Szabo   +7 more
doaj   +1 more source

Glutamine Deprivation Promotes the Generation and Mobilization of MDSCs by Enhancing Expression of G-CSF and GM-CSF

Frontiers in Immunology, 2021
Solid tumors are often challenged by hypoxic and nutrient-deprived tumor microenvironments (TME) as tumors progress, due to limited perfusion and rapid nutrient consumption.
Hong-Wei Sun, Hong-Wei Sun, Wen-Chao Wu, Hai-Tian Chen, Yi-Tuo Xu, Yi-Tuo Xu, Yan-Yan Yang, Yan-Yan Yang, Jing Chen, Xing-Juan Yu, Zilian Wang, Ze-Yu Shuang, Ze-Yu Shuang, Limin Zheng, Limin Zheng   +14 more
doaj   +1 more source

Molecular Cloning, Expression and Purification of G-CSF Isoform D, an Alternative Splice Variant of Human G-CSF

Iranian Journal of Allergy, Asthma and Immunology, 2019
Granulocyte colony-stimulating factor (G-CSF) is the major regulator of hemopoiesis and granulopoiesis. However, overexpression of G-CSF has been implicated in several important processes in tumor biology such as tumor growth, angiogenesis, and ...
Fatemeh Sadat Toghraie, Mahsa Yazdanpanah-Samani, Elham Mahmoudi Maymand, Ahmad Hosseini, Amir Asgari, Amin Ramezani, Abbas Ghaderi   +6 more
doaj   +1 more source

G-CSF and G-CSFR Modulate CD4 and CD8 T Cell Responses to Promote Colon Tumor Growth and Are Potential Therapeutic Targets

Frontiers in Immunology, 2020
Cytokines are known to shape the tumor microenvironment and although progress has been made in understanding their role in carcinogenesis, much remains to learn regarding their role in tumor growth and progression.
Ioannis Karagiannidis, Stephanie J. Jerman, Damian Jacenik, Damian Jacenik, Brandon B. Phinney, Ruoxin Yao, Eric R. Prossnitz, Ellen J. Beswick   +7 more
doaj   +1 more source