Results 51 to 60 of about 310,082 (306)

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

سطح سرمی عوامل محرک کلونی گرانولوسیتی، ماکروفاژی و گرانولوسیتی- ماکروفاژی در خون محیطی بیماران مبتلا به تومور پستان [PDF]

مجله دانشگاه علوم پزشکی سبزوار, 2019
زمینه و هدف: عوامل محرک کلونیگلیکوپروتئین‌هایی هستند که تکثیر و تمایز سلول‌های پیش‌ساز خونساز را در مغز استخوان تحریک میکنند. اما مطالعات متعدد نشان داده اند این فاکتورها می توانند سبب تحریک تکثیر سلولهای غیر خونساز، از جمله سلول‌های سرطانی نیز شوند.
محبوبه رزمخواه, پریسا کریم زاده, فاطمه اقبالی, سمیه رضایی فرد, زهرا فقیه   +4 more
doaj  

The novel CXCR4 antagonist POL5551 mobilizes hematopoietic stem and progenitor cells with greater efficiency than Plerixafor [PDF]

, 2013
Mobilized blood has supplanted bone marrow (BM) as the primary source of hematopoietic stem cells for autologous and allogeneic stem cell transplantation.
A Dar, A D’Souza, A Foudi, A Nagler, A Peled, AM Greenbaum, AW Roberts, B Nervi, CC Bleul, CL Semerad, D Obrecht, DE Harrison, F Ferraro, F Liu, GA Velders, GL Uy, H Balaguer, H Bonig, H Bonig, H Bonig, H Bonig, H Bonig, HE Broxmeyer, IG Winkler, JP Levesque, JP Levesque, K Balabanian, MA Pulsipher, MA Ryan, MJ Christopher, MM Mueller, MP Rettig, MZ Ratajczak, N Amariglio, P Anderlini, P Anderlini, P Anderlini, S Akizuki, SJ DeMarco, SJ Szilvassy, SM Devine, SP Fricker, T Lapidot, TA Lane, V Saini, WC Liles, Y Katayama, Y Takamatsu   +47 more
core   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Randomized and dose-escalation trials of recombinant human serum albumin /granulocyte colony-stimulating factor in patients with breast cancer receiving anthracycline-containing chemotherapy

BMC Cancer, 2021
Background To evaluate the efficacy and safety of recombinant human serum albumin /granulocyte colony-stimulating factor (rHSA/G-CSF) in breast cancer following receipt of cytotoxic agents.
Shanshan Chen, Yiqun Han, Quchang Ouyang, Jianguo Lu, Qingyuan Zhang, Shun’e Yang, Jingfen Wang, Haixin Huang, Hong Liu, Zhimin Shao, Hui Li, Zhendong Chen, Sanyuan Sun, Cuizhi Geng, Junguo Lu, Jianwei Sun, Jiayu Wang, Binghe Xu   +17 more
doaj   +1 more source

Pathophysiological Roles of G-CSF

Journal of Nutritional Science and Vitaminology, 1992
G-CSF is produced by a variety of cells. In situ hybridization showed that only a small proportion of stromal cells expressed G-CSF after stimulation with LPS or IL-1. The measurement of serum G-CSF level by enzyme immunoassay provided valuable information as to the pathophysiological roles of G-CSF. In aplastic anemia, there was an inverse correlation
K. OZAWA, K. WATARI, T. TSURUTA, S. TAKAHASHI, H. OGURA, T. YOSHIKUBO, M. NISHIKAWA, M. SHIMANE, S. OKAMOTO, A. TOJO, K. TANI, S. ASANO   +11 more
openaire   +3 more sources

G-CSF, the guardian of granulopoiesis

Seminars in Immunology, 2021
A considerable amount of continuous proliferation and differentiation is required to produce daily a billion new neutrophils in an adult human. Of the few cytokines and factors known to control neutrophil production, G-CSF is the guardian of granulopoiesis.
Hrishikesh M. Mehta, Seth J. Corey
openaire   +2 more sources

Cost-effectiveness of febrile neutropenia prevention with primary versus secondary G-CSF prophylaxis for adjuvant chemotherapy in breast cancer: a systematic review [PDF]

, 2016
The adoption of primary (PP) versus secondary prophylaxis (SP) of febrile neutropenia (FN), with granulocyte colony-stimulating factors (G-CSF), for adjuvant chemotherapy (AC) regimens in breast cancer (BC) could be affected by its “value for money ...
A Briggs, C Skedgel, C. Skedgel, CJ Murray, D Greenberg, D. Rayson, E Marseille, EK Lee, GH Lyman, GH Lyman, H Mason, H Roche, J Crawford, J Naurois De, JL Yu, KL Cooper, M Aapro, M Martin, MS Aapro, N Lathia, NM Kuderer, P Renner, P Trueman, S Whyte, S. Jovanovic, SD Ramsey, SE Jones, SS Rajan, T Younis, T. Younis, TJ Smith, YC Shih   +31 more
core   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

The Effect of Granulocyte Colony–Stimulating Factor on Immune-Modulatory Cytokines in the Bone Marrow Microenvironment and Mesenchymal Stem Cells of Healthy Donors [PDF]

, 2011
Granulocyte colony stimulating factor (G-CSF) is sometimes administered to donors before bone marrow (BM) harvest. G-CSF–primed (G-BM) and unprimed BM (U-BM)–derived mesenchymal stem cells (MSC) were obtained from 16 healthy donors and were expanded in ...
Ok Bozkaya, Ikbal, Azik, Fatih, Tavil, Betul, Koksal, Yasin, Ozguner, Meltem, Tunc, Bahattin, Uckan Cetinkaya, Duygu   +6 more
core   +1 more source