Results 41 to 50 of about 9,409,602 (307)

Development and characterization of a novel fusion protein of a mutated granulocyte colony-stimulating factor and human serum albumin in Pichia pastoris. [PDF]

PLoS ONE, 2014
The purpose of the present work was to develop a novel, long-acting and potent human serum albumin/granulocyte colony stimulating factor (HSA/G-CSF) therapeutic fusion protein.
Yan-Shan Huang, Xiao-Fang Wen, Zhi-Yu Yang, Yi-Liang Wu, You Lu, Lin-Fu Zhou   +5 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

G-CSF and GM-CSF in Neutropenia [PDF]

The Journal of Immunology, 2015
Abstract G-CSF and GM-CSF are used widely to promote the production of granulocytes or APCs. The U.S. Food and Drug Administration approved G-CSF (filgrastim) for the treatment of congenital and acquired neutropenias and for mobilization of peripheral hematopoietic progenitor cells for stem cell transplantation.
Hrishikesh M, Mehta, Michael, Malandra, Seth J, Corey   +2 more
openaire   +2 more sources

Traumatic CSF Leaks

, 2022
The majority of cerebrospinal fluid (CSF) leaks result from some form of skull base trauma. Injuries to the base of skull can be the result of accidental injury or intraoperative (iatrogenic) injury. The type of injury can have an important impact on CSF
Al-Bar, Mohammad H., Folbe, Adam J., Levine, Corinna G.   +2 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

G‐CSF induces CD15+ CD14+ cells from granulocytes early in the physiological environment of pregnancy and the cancer immunosuppressive microenvironment

Clinical & Translational Immunology, 2022
Objectives Recombinant granulocyte colony‐stimulating factor (G‐CSF) is frequently administered to patients with cancer to enhance granulocyte recovery post‐chemotherapy. Clinical trials have also used G‐CSF to modulate myeloid cell function in pregnancy
Ebtehag Maneta, Livingstone Fultang, Jemma Taylor, Matthew Pugh, William Jenkinson, Graham Anderson, Arri Coomarasamy, Mark D Kilby, David M Lissauer, Francis Mussai, Carmela De Santo   +10 more
doaj   +1 more source

The receptor for Granulocyte-colony stimulating factor (G-CSF) is expressed in radial glia during development of the nervous system-1

, 2011
-PCR products of the following stages were loaded on the gels: E11, E12, E14, E16, E18 and P2. As positive controls for G-CSF and G-CSF receptor sequence-verified cDNA clones were used. The negative control consisted of water. RNA was prepared out of E11
Armin Schneider (66478), Carola Krüger (66481), Friederike Kirsch (91001)   +2 more
core   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

سطح سرمی عوامل محرک کلونی گرانولوسیتی، ماکروفاژی و گرانولوسیتی- ماکروفاژی در خون محیطی بیماران مبتلا به تومور پستان [PDF]

مجله دانشگاه علوم پزشکی سبزوار, 2019
زمینه و هدف: عوامل محرک کلونیگلیکوپروتئین‌هایی هستند که تکثیر و تمایز سلول‌های پیش‌ساز خونساز را در مغز استخوان تحریک میکنند. اما مطالعات متعدد نشان داده اند این فاکتورها می توانند سبب تحریک تکثیر سلولهای غیر خونساز، از جمله سلول‌های سرطانی نیز شوند.
محبوبه رزمخواه, پریسا کریم زاده, فاطمه اقبالی, سمیه رضایی فرد, زهرا فقیه   +4 more
doaj