Results 71 to 80 of about 9,409,602 (307)

Efficacy and Toxicity of Cytarabine + G-CSF, Cyclophosphamide + G-CSF, and Plerixafor + G-CSF Mobilization of Autologous Hematopoietic Stem Cells in Hematologic Malignancy Patients with Predicted Poor Collection

Клиническая онкогематология
AIM. To compare the efficacy and toxicity of various regimens of autologous hematopoietic stem cell (HSC) mobilization (cytarabine + G-CSF, cyclophosphamide + G-CSF, and plerixafor + G-CSF) in hematologic malignancy patients with predicted poor HSC ...
Svetlana Sergeevna Elkhova, L. V. Filatova, I. S. Zyuzgin, S. A. Volchenkov, L. A. Kramynin, T. Yu. Semiglazova   +5 more
doaj   +1 more source

Both systemic and local application of Granulocyte-colony stimulating factor (G-CSF) is neuroprotective after retinal ganglion cell axotomy

BMC Neuroscience, 2009
Background The hematopoietic Granulocyte-Colony Stimulating Factor (G-CSF) plays a crucial role in controlling the number of neutrophil progenitor cells.
Dietz Gunnar PH, Rohde Gundula, Meuer Katrin, Göricke Bettina, Schlachetzki Johannes CM, Frank Tobias, Bähr Mathias, Schneider Armin, Weishaupt Jochen H   +8 more
doaj   +1 more source

The novel CXCR4 antagonist POL5551 mobilizes hematopoietic stem and progenitor cells with greater efficiency than Plerixafor

, 2013
Mobilized blood has supplanted bone marrow (BM) as the primary source of hematopoietic stem cells for autologous and allogeneic stem cell transplantation.
Dembowsky, K., Dembowsky, Klaus, Romagnoli, B., G Spohn, Karpova, Darja, Patel, K., Chevalier, E., Levesque, J. P., E Chevalier, D Karpova, Patel, Kalpana, Spohn, Gabriele, Romagnoli, Barbara, Schulz, M., Wiercinska, Eliza, Chevalier, Eric, H Bonig, K Dauber, E Wiercinska, J P Levesque, Schulz, Miriam, Chudziak, D., K Dembowsky, Dauber, Katrin, Karpova, D., B Romagnoli, A R Pettit, Wiercinska, E., D Chudziak, Levesque, Jean-Pierre, Bönig, Halvard-Björn, Spohn, G., Pettit, Allison R., M Schulz, K Patel, Bonig, H., Pettit, A. R., Chudziak, Doreen, Dauber, K.   +38 more
core   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Inhibition by Rapamycin of the Lipoteichoic Acid-Induced Granulocyte- Colony Stimulating Factor Expression in Mouse Macrophages

, 2012
Granulocyte-colony stimulating factor G-CSF is a cytokine which involves in anti-inflammation and inflammation as well . Rapamycin is an inhibitor of mTOR which also plays a role in innate immunity.
CHOU, YUAN-YI;LU, SHAO-CHUN, 周苑怡;呂紹俊   +1 more
core   +1 more source

Immunohistochemical Study on the Expression of G-CSF, G-CSFR, VEGF, VEGFR-1, Foxp3 in First Trimester Trophoblast of Recurrent Pregnancy Loss in Pregnancies Treated with G-CSF and Controls. [PDF]

, 2019
BACKGROUND: Recurrent Pregnancy Loss (RPL) is a syndrome recognizing several causes, and in some cases the treatment with Granulocyte Colony Stimulating Factor (G-CSF) may be successful, especially when karyotype of the previous miscarriage showed no ...
Rossi G, Klinger FG, Sbracia M., Scarpellini F   +3 more
core   +1 more source

Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab‐treated patients with at least
Kimberly H. Markowitz, Neha V. Safi, Iliana Pliska‐Bloch, Ulrike W. Kaunzner, Ha Luu, Mert Sisman, Yi Wang, Thanh D. Nguyen, Sandra Hurtado Rúa, Susan A. Gauthier   +9 more
wiley   +1 more source

A Case of Granulocyte Colony-Stimulating Factor (G-CSF)-Producing Lung Cancer Proved by Immunohistochemical Analysis

, 1993
症例は59歳, 男性で全身倦怠感および咳嗽を主訴として来院した.胸部X線写真では左下肺野に浸潤影を伴う腫瘤影を認めた.検査成績では, 明らかな感染症がないにもかかわらず32, 000/μlと著明な白血球増多がみられた.血清中のG-CSF値は酵素標識免疫法で298pg/mlと高値を示していた。臨床的に病期IIIAの肺扁平上皮癌と診断し, 左肺全剔術を施行した.手術時に得られた腫傷組織の抽出液および腫傷細胞の組織培養上清のG-CSF濃度は高値であった.rhG ...
南, 寛行, 増本, 英男, 浅井, 貞宏, 荒木, 潤, 早田, 宏, 阿部, 良行   +5 more
core  

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source