Results 91 to 100 of about 12,166,273 (260)

Lack of effect of the human GM-CSF analog E21R on the survival of primary human acute myeloid leukemia cells [PDF]

, 2004
The granulocyte-macrophage colony-stimulating factor (GM-CSF) analog E21R binds to the GM-CSF receptor complex with low affinity and acts as a competitive antagonist.
Jakupovic, I., Khwaja, A., Grandage, V.L., Linch, D.C.   +3 more
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G-CSF and GM-CSF Modify Neutrophil Functions at Concentrations found in Cystic Fibrosis. [PDF]

, 2019
The role of colony stimulating factors (CSFs) in cystic fibrosis (CF) circulating neutrophils has not been thoroughly evaluated, considering that the neutrophil burden of lung inflammation in these subjects is very high.
Diana A., Vinella A., De Venuto D, Leonetti G, De Venuto D., Montemurro P, Polizzi A. M., Guerra L, D'Oria S, Mariggiò MA, D'Oria S., Castellani S, Gallo C, Montemurro P., Castellani S., Mariggio M. A., Favia M, Guerra L., Leonetti G., Diana A, Di Gioia S, Favia M., Gallo C., Conese M., Polizzi AM, Vinella A, Di Gioia S.   +26 more
core   +1 more source

Metabolic and Fluid Biomarkers Support Microglia Activation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis is an incurable neurodegenerative disease involving motor neuron degeneration and metabolic and immune dysfunction. We combined clinical data, cerebrospinal fluid biomarkers and fluorodeoxyglucose positron emission tomography with magnetic resonance imaging to investigate the role of reactive microglia in disease ...
Matteo Zanovello, Francesca Serani, Alen Bebeti, Federica Paredi, Giulia Quadrio, Andrea Fortuna, Giacomo Maria Minicuci, Elena Pegoraro, Annachiara Cagnin, Diego Cecchin, Gianni Sorarù   +10 more
wiley   +1 more source

Diffuse MRI Edema Predicts Relapse in Cerebral Amyloid Angiopathy–Related Inflammation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify MRI predictors of relapse and quantify relapse and mortality risk in cerebral amyloid angiopathy–related inflammation (CAA‐RI). A secondary objective was to assess the association between mycophenolate mofetil use and relapse risk. Methods We performed a retrospective cohort study of 36 patients with CAA‐RI treated at the
G. Abbas Kharal, Gowtham Yerneni, Kim J. Griffin, Nicolas Thompson, Ken Uchino, Irene Katzan, Dolora Wisco, Abeer Farrag, Jayashree Sundarajan, Andrew Russman, M. Shazam Hussain   +10 more
wiley   +1 more source

Pegylated granulocyte colony-stimulating factor mobilizes CD34+ cells with different stem and progenitor subsets and distinct functional properties in comparison with unconjugated granulocyte colony-stimulating factor

Haematologica, 2008
Background Pegylated granulocyte colony-stimulating factor (G-CSF) has recently been introduced as a new compound for mobilization of CD34+ hematopoietic stem and progenitor cells.
Ingmar Bruns, Ulrich Steidl, Johannes C. Fischer, Akos Czibere, Guido Kobbe, Sascha Raschke, Raminder Singh, Roland Fenk, Michael Rosskopf, Sabrina Pechtel, Arndt von Haeseler, Peter Wernet, Daniel G. Tenen, Rainer Haas, Ralf Kronenwett   +14 more
doaj   +1 more source

Association Between Neurofilament Light Chain and Real‐World Ambulatory Function in Progressive MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurofilament light chain (NfL) is a biomarker of neuroaxonal injury in multiple sclerosis (MS), yet associations with functional outcomes remain unclear. Longitudinal associations between serum NfL (sNfL) and daily step count (STEPS) from wearable devices were assessed in a large international progressive MS cohort.
Gabby B. Joseph, Megan McCune, Riley Bove, Ahmed Abdelhak, Bruce A. C. Cree, Valerie J. Block   +5 more
wiley   +1 more source

Glioblastoma-synthesized G-CSF and GM-CSF contribute to growth and immunosuppression: Potential therapeutic benefit from dapsone, fenofibrate, and ribavirin

Tumor Biology, 2017
Increased ratio of circulating neutrophils to lymphocytes is a common finding in glioblastoma and other cancers. Data reviewed establish that any damage to brain tissue tends to cause an increase in G-CSF and/or GM-CSF (G(M)-CSF) synthesized by the brain.
Richard E Kast, Quentin A Hill, Didier Wion, Håkan Mellstedt, Daniele Focosi, Georg Karpel-Massler, Tim Heiland, Marc-Eric Halatsch   +7 more
doaj   +1 more source

Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai, Audrey Zhu, Chunxuan Ma, Ming Wang, Yifan Yang, Lynn M. Bekris, Maria Khrestian, Frank P. DiFilippo, Mikhail Nasrallah, Aaron Burberry, James B. Leverenz, Yuan Hou, Feixiong Cheng, Stephen M. Rao   +13 more
wiley   +1 more source

Granulocyte colony-stimulating factor and leukemogenesis

Mediators of Inflammation, 2004
THE granulocyte colony-stimulating factor (G-CSF) plays an important role in normal granulopoiesis. Its functions are mediated by specific receptors on the surface of responsive cells and, upon ligand binding, several cytoplasmic tyrosine kinases are ...
Lorena Lobo de Figueiredo, Rodrigo Siqueira de Abreu e Lima, Eduardo Magalhães Rego   +2 more
doaj   +1 more source

Recognition of handwritten digits by features and a multi-layer perceptron

, 1992
International audienceHandwritten digit recognition was one of the first areas in which neural network technology was applied. Thomson-CSF/LER has developed an intermediate approach between classical methods, based on extracting small sets of parameters,
Pottier, Isabelle, Burel, Gilles
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