Results 1 to 10 of about 323,368 (289)

Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use [PDF]

Nature Communications, 2023
Dietary polyunsaturated fatty acids (PUFA) are increasingly recognized for their health benefits, whereas a high production of endogenous fatty acids – a process called de novo lipogenesis (DNL) - is closely linked to metabolic diseases.
Anna Worthmann, Julius Ridder, Sharlaine Y. L. Piel, Ioannis Evangelakos, Melina Musfeldt, Hannah Voß, Marie O’Farrell, Alexander W. Fischer, Sangeeta Adak, Monica Sundd, Hasibullah Siffeti, Friederike Haumann, Katja Kloth, Tatjana Bierhals, Markus Heine, Paul Pertzborn, Mira Pauly, Julia-Josefine Scholz, Suman Kundu, Marceline M. Fuh, Axel Neu, Klaus Tödter, Maja Hempel, Uwe Knippschild, Clay F. Semenkovich, Hartmut Schlüter, Joerg Heeren, Ludger Scheja, Christian Kubisch, Christian Schlein   +29 more
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Composition and synthesis of fatty acids in atherosclerotic aortas of the pigeon

Journal of Lipid Research, 1968
The composition, synthesis, and esterification of fatty acids were studied in aortas of White Carneau and Show Racer pigeons after perfusion of the aortas with a medium containing acetate-1-14C.For both breeds of pigeons the principal change in aortic ...
Richard W. St. Clair, Hugh B. Lofland, Jr., Thomas B. Clarkson   +2 more
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The proto-oncogene tyrosine kinase c-SRC facilitates glioblastoma progression by remodeling fatty acid synthesis [PDF]

Nature Communications
Increased fatty acid synthesis benefits glioblastoma malignancy. However, the coordinated regulation of cytosolic acetyl-CoA production, the exclusive substrate for fatty acid synthesis, remains unclear.
Wentao Zhao, Cong Ouyang, Liang Zhang, Jinyang Wang, Jiaojiao Zhang, Yan Zhang, Chen Huang, Qiao Xiao, Bin Jiang, Furong Lin, Cixiong Zhang, Mingxia Zhu, Changchuan Xie, Xi Huang, Bingchang Zhang, Wenpeng Zhao, Jiawei He, Sifang Chen, Xiyao Liu, Donghai Lin, Qinxi Li, Zhanxiang Wang   +21 more
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Nitrogen starvation leads to TOR kinase-mediated downregulation of fatty acid synthesis in the algae Chlorella sorokiniana and Chlamydomonas reinhardtii [PDF]

BMC Plant Biology
Background When subject to stress conditions such as nutrient limitation microalgae accumulate triacylglycerol (TAG). Fatty acid, a substrate for TAG synthesis is derived from de novo synthesis or by membrane remodeling.
Jithesh Vijayan, Sophie Alvarez, Michael J. Naldrett, Wyatt Morse, Amanda Maliva, Nishikant Wase, Wayne R. Riekhof   +6 more
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SCO6564, a novel 3-ketoacyl acyl carrier protein synthase III, contributes in fatty acid synthesis in Streptomyces coelicolor. [PDF]

PLoS ONE
The genus Streptomyces comprises gram-positive bacteria that produce large numbers of secondary metabolites, which have promising commercial applications and deserve extensive study.
Jian-Rong Ma, Jia-Ying Lin, Yuan-Yin Zhang, Yun Chen, Wen-Bing Zhang, Xian-Pu Ni, Yong-Hong Yu   +6 more
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Surplus fatty acid synthesis increases oxidative stress in adipocytes and induces lipodystrophy [PDF]

Nature Communications
Adipocytes are the primary sites for fatty acid storage, but the synthesis rate of fatty acids is very low. The physiological significance of this phenomenon remains unclear.
Li Weng, Wen-Shuai Tang, Xu Wang, Yingyun Gong, Changqin Liu, Ni-Na Hong, Ying Tao, Kuang-Zheng Li, Shu-Ning Liu, Wanzi Jiang, Ying Li, Ke Yao, Li Chen, He Huang, Yu-Zheng Zhao, Ze-Ping Hu, Youli Lu, Haobin Ye, Xingrong Du, Hongwen Zhou, Peng Li, Tong-Jin Zhao   +21 more
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The Enterococcus faecalis FabT Transcription Factor Regulates Fatty Acid Biosynthesis in Response to Exogeneous Fatty Acids

Frontiers in Microbiology, 2022
The phospholipid acyl chains of Enterococcus faecalis can be derived either by de novo synthesis or by incorporation of exogenous fatty acids through the fatty acid kinase complex (Fak)-phosphate acyltransferase (PlsX) pathway.
Qi Zou, Huijuan Dong, Lei Zhu, John E. Cronan, John E. Cronan   +4 more
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SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids. [PDF]

PLoS ONE, 2012
Increased metabolism is a requirement for tumor cell proliferation. To understand the dependence of tumor cells on fatty acid metabolism, we evaluated various nodes of the fatty acid synthesis pathway.
Paul Mason, Beirong Liang, Lingyun Li, Trisha Fremgen, Erin Murphy, Angela Quinn, Stephen L Madden, Hans-Peter Biemann, Bing Wang, Aharon Cohen, Svetlana Komarnitsky, Kate Jancsics, Brad Hirth, Christopher G F Cooper, Edward Lee, Sean Wilson, Roy Krumbholz, Steven Schmid, Yibin Xiang, Michael Booker, James Lillie, Kara Carter   +21 more
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Upregulation of Superenhancer‐Driven LncRNA FASRL by USF1 Promotes De Novo Fatty Acid Biosynthesis to Exacerbate Hepatocellular Carcinoma

Advanced Science, 2023
Superenhancers drive abnormal gene expression in tumors and promote malignancy. However, the relationship between superenhancer‐associated long noncoding RNA (lncRNA) and abnormal metabolism is unknown.
Jiang‐Yun Peng, Dian‐Kui Cai, Ren‐Li Zeng, Chao‐Yang Zhang, Guan‐Cheng Li, Si‐Fan Chen, Xiao‐Qing Yuan, Li Peng   +7 more
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Enterococcus faecalis Encodes an Atypical Auxiliary Acyl Carrier Protein Required for Efficient Regulation of Fatty Acid Synthesis by Exogenous Fatty Acids

mBio, 2019
Acyl carrier proteins (ACPs) play essential roles in the synthesis of fatty acids and transfer of long fatty acyl chains into complex lipids. The Enterococcus faecalis genome contains two annotated acp genes, called acpA and acpB.
Lei Zhu, Qi Zou, Xinyun Cao, John E. Cronan   +3 more
doaj   +1 more source