Results 1 to 10 of about 1,679,926 (396)

Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use

Nature Communications, 2023
Dietary polyunsaturated fatty acids (PUFA) are increasingly recognized for their health benefits, whereas a high production of endogenous fatty acids – a process called de novo lipogenesis (DNL) - is closely linked to metabolic diseases.
Anna Worthmann, Julius Ridder, Sharlaine Y. L. Piel, Ioannis Evangelakos, Melina Musfeldt, Hannah Voß, Marie O’Farrell, Alexander W. Fischer, Sangeeta Adak, Monica Sundd, Hasibullah Siffeti, Friederike Haumann, Katja Kloth, Tatjana Bierhals, Markus Heine, Paul Pertzborn, Mira Pauly, Julia-Josefine Scholz, Suman Kundu, Marceline M. Fuh, Axel Neu, Klaus Tödter, Maja Hempel, Uwe Knippschild, Clay F. Semenkovich, Hartmut Schlüter, Joerg Heeren, Ludger Scheja, Christian Kubisch, Christian Schlein   +29 more
doaj   +4 more sources

Engineering the fatty acid synthesis pathway in Synechococcus elongatus PCC 7942 improves omega-3 fatty acid production

Biotechnology for Biofuels, 2018
Background The microbial production of fatty acids has received great attention in the last few years as feedstock for the production of renewable energy.
María Santos-Merino, M. Pilar Garcillán-Barcia, Fernando de la Cruz   +2 more
doaj   +2 more sources

Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models. [PDF]

Nature Medicine, 2016
Continuous de novo fatty acid synthesis is a common feature of cancer that is required to meet the biosynthetic demands of a growing tumor. This process is controlled by the rate-limiting enzyme acetyl-CoA carboxylase (ACC), an attractive but ...
Bhat, Sathesh, Brun, Sonja N, Eichner, Lillian J, Gerken, Laurie, Greenwood, Jeremy, Harriman, Geraldine, Harwood, H James, Hutchins, Amanda, Kapeller, Rosana, Kolar, Matthew J, Lombardo, Portia S, Metallo, Christian M, Parker, Seth J, Saghatelian, Alan, Shaw, Reuben J, Svensson, Robert U, Van Nostrand, Jeanine L, Vera, Lilliana, Wallace, Martina, Westlin, William F   +19 more
core   +2 more sources

The proto-oncogene tyrosine kinase c-SRC facilitates glioblastoma progression by remodeling fatty acid synthesis [PDF]

Nature Communications
Increased fatty acid synthesis benefits glioblastoma malignancy. However, the coordinated regulation of cytosolic acetyl-CoA production, the exclusive substrate for fatty acid synthesis, remains unclear.
Wentao Zhao, Cong Ouyang, Liang Zhang, Jinyang Wang, Jiaojiao Zhang, Yan Zhang, Chen Huang, Qiao Xiao, Bin Jiang, Furong Lin, Cixiong Zhang, Mingxia Zhu, Changchuan Xie, Xi Huang, Bingchang Zhang, Wenpeng Zhao, Jiawei He, Sifang Chen, Xiyao Liu, Donghai Lin, Qinxi Li, Zhanxiang Wang   +21 more
doaj   +2 more sources

Tailored fatty acid synthesis via dynamic control of fatty acid elongation [PDF]

Proceedings of the National Academy of Sciences, 2013
Medium-chain fatty acids (MCFAs, 4–12 carbons) are valuable as precursors to industrial chemicals and biofuels, but are not canonical products of microbial fatty acid synthesis. We engineered microbial production of the full range of even- and odd-chain–length MCFAs and found that MCFA production is limited by rapid, irreversible elongation of their ...
Joseph P, Torella, Tyler J, Ford, Scott N, Kim, Amanda M, Chen, Jeffrey C, Way, Pamela A, Silver   +5 more
openaire   +3 more sources

The fatty acid synthesis gene fabY affects lipopolysaccharide synthesis and colistin susceptibility in Pseudomonas aeruginosa [PDF]

Microbiology Spectrum
Bacterial metabolism impacts susceptibility to antibiotics. Here, we found that mutation of the Pseudomonas aeruginosa fatty acid response regulator gene pvrA decreases bacterial susceptibility to colistin.
Dandan Zhou, Xiaoya Wei, Yongxin Jin, Zhihui Cheng, Shouguang Jin, Un-Hwan Ha, Xiaolei Pan, Weihui Wu   +7 more
doaj   +2 more sources

Inhibition of de novo fatty acid synthesis in Mycobacterium tuberculosis. [PDF]

J Biol Chem
Roszkowski EK, Charap S, Montague CR, Sukheja P, McNamara CW, Soma PS, Islam MN, Graham B, Grzegorzewicz AE, Jackson M, Yang B, Hay AG, Russell DG, Belisle JT, VanderVen BC.   +14 more
europepmc   +2 more sources

SCO6564, a novel 3-ketoacyl acyl carrier protein synthase III, contributes in fatty acid synthesis in Streptomyces coelicolor. [PDF]

PLoS ONE
The genus Streptomyces comprises gram-positive bacteria that produce large numbers of secondary metabolites, which have promising commercial applications and deserve extensive study.
Jian-Rong Ma, Jia-Ying Lin, Yuan-Yin Zhang, Yun Chen, Wen-Bing Zhang, Xian-Pu Ni, Yong-Hong Yu   +6 more
doaj   +2 more sources

Surplus fatty acid synthesis increases oxidative stress in adipocytes and induces lipodystrophy [PDF]

Nature Communications
Adipocytes are the primary sites for fatty acid storage, but the synthesis rate of fatty acids is very low. The physiological significance of this phenomenon remains unclear.
Li Weng, Wen-Shuai Tang, Xu Wang, Yingyun Gong, Changqin Liu, Ni-Na Hong, Ying Tao, Kuang-Zheng Li, Shu-Ning Liu, Wanzi Jiang, Ying Li, Ke Yao, Li Chen, He Huang, Yu-Zheng Zhao, Ze-Ping Hu, Youli Lu, Haobin Ye, Xingrong Du, Hongwen Zhou, Peng Li, Tong-Jin Zhao   +21 more
doaj   +2 more sources

The Enterococcus faecalis FabT Transcription Factor Regulates Fatty Acid Biosynthesis in Response to Exogeneous Fatty Acids

Frontiers in Microbiology, 2022
The phospholipid acyl chains of Enterococcus faecalis can be derived either by de novo synthesis or by incorporation of exogenous fatty acids through the fatty acid kinase complex (Fak)-phosphate acyltransferase (PlsX) pathway.
Qi Zou, Huijuan Dong, Lei Zhu, John E. Cronan, John E. Cronan   +4 more
doaj   +1 more source