Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use [PDF]
Nature Communications, 2023 Dietary polyunsaturated fatty acids (PUFA) are increasingly recognized for their health benefits, whereas a high production of endogenous fatty acids – a process called de novo lipogenesis (DNL) - is closely linked to metabolic diseases.
Anna Worthmann +29 more
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The proto-oncogene tyrosine kinase c-SRC facilitates glioblastoma progression by remodeling fatty acid synthesis [PDF]
Nature CommunicationsIncreased fatty acid synthesis benefits glioblastoma malignancy. However, the coordinated regulation of cytosolic acetyl-CoA production, the exclusive substrate for fatty acid synthesis, remains unclear.
Wentao Zhao +21 more
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Composition and synthesis of fatty acids in atherosclerotic aortas of the pigeon
Journal of Lipid Research, 1968 The composition, synthesis, and esterification of fatty acids were studied in aortas of White Carneau and Show Racer pigeons after perfusion of the aortas with a medium containing acetate-1-14C.For both breeds of pigeons the principal change in aortic ...
Richard W. St. Clair +2 more
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Nitrogen starvation leads to TOR kinase-mediated downregulation of fatty acid synthesis in the algae Chlorella sorokiniana and Chlamydomonas reinhardtii [PDF]
BMC Plant BiologyBackground When subject to stress conditions such as nutrient limitation microalgae accumulate triacylglycerol (TAG). Fatty acid, a substrate for TAG synthesis is derived from de novo synthesis or by membrane remodeling.
Jithesh Vijayan +6 more
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SCO6564, a novel 3-ketoacyl acyl carrier protein synthase III, contributes in fatty acid synthesis in Streptomyces coelicolor. [PDF]
PLoS ONEThe genus Streptomyces comprises gram-positive bacteria that produce large numbers of secondary metabolites, which have promising commercial applications and deserve extensive study.
Jian-Rong Ma +6 more
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Surplus fatty acid synthesis increases oxidative stress in adipocytes and induces lipodystrophy [PDF]
Nature CommunicationsAdipocytes are the primary sites for fatty acid storage, but the synthesis rate of fatty acids is very low. The physiological significance of this phenomenon remains unclear.
Li Weng +21 more
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Microsomal Synthesis of Fatty Acid Amides [PDF]
Journal of Biological Chemistry, 1966 Abstract A microsomal system is described which catalyzes the formation of fatty acid amides of ethanolamine and of several pharmacologically active amines. Although the system has no dependance on external energy sources and has a high Km for the amine substrate, it has several characteristics which differ markedly from an amide hydrolytic system in ...
Nicholas R. Bachur, Sidney Udenfriend
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Mechanism of fatty acid synthesis* [PDF]
Journal of Lipid Research, 1961 Salih J. Wakil
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Frontiers in Microbiology, 2022 The phospholipid acyl chains of Enterococcus faecalis can be derived either by de novo synthesis or by incorporation of exogenous fatty acids through the fatty acid kinase complex (Fak)-phosphate acyltransferase (PlsX) pathway.
Qi Zou +4 more
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SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids. [PDF]
PLoS ONE, 2012 Increased metabolism is a requirement for tumor cell proliferation. To understand the dependence of tumor cells on fatty acid metabolism, we evaluated various nodes of the fatty acid synthesis pathway.
Paul Mason +21 more
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