Results 111 to 120 of about 1,679,926 (396)

HMG-CoA reductase inhibitors perturb fatty acid metabolism and induce peroxisomes in keratinocytes.

Journal of Lipid Research, 1992
Topical lovastatin stimulates epidermal fatty acid synthesis in vivo; therefore, studies were undertaken to examine the effects of HMG-CoA reductase inhibitors on fatty acid metabolism in cultured keratinocytes.
ML Williams, GK Menon, KP Hanley
doaj   +1 more source

Enhancing microRNA167A expression in seed decreases the α-linolenic acid content and increases seed size in Camelina sativa. [PDF]

, 2019
Despite well established roles of microRNAs in plant development, few aspects have been addressed to understand their effects in seeds especially on lipid metabolism.
Grabowski, Paul, Lu, Chaofu, Mu, Xiaopeng, Na, GunNam, Schmutz, Jeremy   +4 more
core   +1 more source

Relapsing–Remitting Multiple Sclerosis Is Associated With a Dysbiotic Oral Microbiome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurological impairment. While the gut microbiota's role in MS is extensively studied, the association between the oral microbiota and MS remains underexplored, particularly in North American cohorts.
Sukirth M. Ganesan, Meeta Yadav, Sudeep Ghimire, Peter C. Lehman, Apurva J. Patel, Sydney Woods, Heena Olalde, Jemmie Hoang, Mishelle Paullus, Catherine Cherwin, Christine Gill, Tracey Cho, Ashutosh K. Mangalam   +12 more
wiley   +1 more source

Inhibition of Ubiquitin Ligase F-box and WD Repeat Domain-containing 7α (Fbw7α) Causes Hepatosteatosis through Krüppel-like Factor 5 (KLF5)/Peroxisome Proliferator-activated Receptor γ2 (PPARγ2) Pathway but Not SREBP-1c Protein in Mice [PDF]

, 2011
F-box and WD repeat domain-containing 7α (Fbw7α) is the substrate recognition component of a ubiquitin ligase that controls the degradation of factors involved in cellular growth, including c-Myc, cyclin E, and c-Jun.
Ema Masatsugu, Iwasaki Hitoshi, Karasawa Tadayoshi, Kobayashi Kazuto, Kumadaki Shin, Matsuzaka Takashi, Nakagawa Yoshimi, Nakakuki Masanori, Saito Ryo, Shimano Hitoshi, Sone Hirohito, Suzuki Hiroaki, Takahashi Akimitsu, Takahashi Satoru, Takekoshi Kazuhiro, Yahagi Naoya, Yamada Nobuhiro, Yatoh Shigeru, 中川 嘉, 依馬 正次, 小林 和人, 山田 信博, 岩﨑 仁, 島野 仁, 曽根 博仁, 松坂 賢, 矢作 直也, 矢藤 繁, 竹越 一博, 鈴木 浩明, 高橋 昭光, 高橋 智   +31 more
core   +1 more source

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source

Nitrogen starvation leads to TOR kinase-mediated downregulation of fatty acid synthesis in the algae Chlorella sorokiniana and Chlamydomonas reinhardtii

BMC Plant Biology
Background When subject to stress conditions such as nutrient limitation microalgae accumulate triacylglycerol (TAG). Fatty acid, a substrate for TAG synthesis is derived from de novo synthesis or by membrane remodeling.
Jithesh Vijayan, Sophie Alvarez, Michael J. Naldrett, Wyatt Morse, Amanda Maliva, Nishikant Wase, Wayne R. Riekhof   +6 more
doaj   +1 more source

Transcriptome analyses reveal reduced hepatic lipid synthesis and accumulation in more feed efficient beef cattle [PDF]

, 2018
peer-reviewedThe genetic mechanisms controlling residual feed intake (RFI) in beef cattle are still largely unknown. Here we performed whole transcriptome analyses to identify differentially expressed (DE) genes and their functional roles in liver ...
Fitzsimmons, Carolyn, Keogh, Kate, Li, Changxi, Mukiibi, Robert, Stothard, Paul, Vinsky, Michael, Waters, Sinead M.   +6 more
core   +3 more sources

Fatty acid synthesis is required for breast cancer brain metastasis

Nature Cancer, 2021
G. Ferraro, A. Ali, Alba Luengo, David P. Kodack, A. Deik, Keene L. Abbott, Divya Bezwada, L. Blanc, Brendan Prideaux, Xin Jin, Jessica M Posada, Jiang Chen, Christopher R Chin, Zohreh Amoozgar, Raphael Ferreira, Ivy X. Chen, K. Naxerova, C. Ng, Anna M. Westermark, M. Duquette, S. Roberge, N. Lindeman, C. Lyssiotis, J. Nielsen, D. Housman, D. Duda, E. Brachtel, T. Golub, L. Cantley, J. Asara, S. Davidson, D. Fukumura, V. Dartois, C. Clish, R. Jain, M. V. Vander Heiden   +35 more
semanticscholar   +1 more source

Fatty acid carbon is essential for dNTP synthesis in endothelial cells

Nature, 2015
The metabolism of endothelial cells during vessel sprouting remains poorly studied. Here we report that endothelial loss of CPT1A, a rate-limiting enzyme of fatty acid oxidation (FAO), causes vascular sprouting defects due to impaired proliferation, not ...
Sandra Schoors, Ulrike Bruning, R. Missiaen, K. Queiroz, G. Borgers, Ilaria Elia, A. Zecchin, A. Cantelmo, S. Christen, J. Goveia, W. Heggermont, Lucica Goddé, S. Vinckier, P. V. Van Veldhoven, G. Eelen, L. Schoonjans, H. Gerhardt, M. Dewerchin, M. Baes, Katrien de Bock, B. Ghesquière, Sophia Y. Lunt, S. Fendt, P. Carmeliet   +23 more
semanticscholar   +1 more source

Bimetallic Nanoparticles as Cocatalysts for Photocatalytic Hydrogen Production

Advanced Functional Materials, EarlyView.
Recent developments have introduced bimetallic nanoparticles as effective cocatalysts for photocatalytic systems. This review explores the rapidly expanding research on bimetallic cocatalysts for photocatalytic production of hydrogen, emphasizing the creation of carrier‐selective contacts, localized surface plasmon resonance effects, methodologies for ...
Yufen Chen, Asier Agrelo‐Lestón, Ignasi Burgués‐Ceballos, Jordi Llorca, Lluís Soler   +4 more
wiley   +1 more source